Evidence map›Paper›PMID 35971860›Full record

ArticleArtificial organs2022

Durable scalable 3D SLA-printed cuff electrodes with high performance carbon + PEDOT:PSS-based contacts.

Onna Marie Doering, Christian Vetter, Awadh Alhawwash, M Ryne Horn, Ken Yoshida

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Onna Marie DoeringDepartment of Biomedical Engineering, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0001-9592-174X
Christian VetterDepartment of Biomedical Engineering, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0002-2621-5611
Awadh AlhawwashWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0003-0044-5416
M Ryne HornDepartment of Biomedical Engineering, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0002-1066-6303
Ken YoshidaDepartment of Biomedical Engineering, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0003-4566-580X
Indiana University – Purdue University Indianapolis · USPurdue University West Lafayette · US

Funding

Reversible block of nerve conduction using low frequency alternating currentsR21EB028469 · NIBIB · INDIANA UNIVERSITY INDIANAPOLIS · PI YOSHIDA, KEN · 2019 to 2021
$630k
NIBIB NIH HHS R21 EB028469NIH HHS R21EB028469
6 · The paper itself

Abstract

backgroundThe stimulation and recording performance of implanted neural interfaces are functions of the physical and electrical characteristics of the neural interface, its electrode material and structure. Therefore, rapid optimization of such characteristics is becoming critical in most clinical and research studies. This paper describes the development of an upgraded 3D printed cuff electrode shell design containing a novel intrinsically conductive polymer (ICP) for stimulation and recording of peripheral nerve fibers.

methodsA 3D stereolithography (SLA) printer was used to print a scalable, custom designed, C-cuff electrode and I-beam closure for accurate, rapid implementation. A novel contact consisting of a percolated carbon graphite base electrodeposited with an intrinsically conductive polymer (ICP), poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) produced a PEDOT:PSS + carbon black (CB) matrix that was used to form the electrochemical interface on the structure. Prototype device performance was tested both in-vitro and in-vivo for electrical chemical capacity, electrochemical interfacial impedance, surgical handling, and implantability. The in-vivo work was performed on the sciatic nerve of 25 anesthetized Sprague Dawley rats to demonstrate recording and stimulating ability.

resultsPrototypes of different spatial geometries and number of contacts (bipolar, tripolar, and tetrapolar) were designed. The design was successfully printed with inner diameters down to 500 μm. Standard bipolar and tripolar cuffs, with a 1.3 mm inner diameter (ID), 0.5 mm contact width, 1.0 mm pitch, and a 1.5 mm end distance were used for the functional tests. This geometry was appropriate for placement on the rat sciatic nerve and enabled in-vivo testing in anesthetized rats. The contacts on the standard bipolar electrode had an area of 2.1 × 10

conclusionsThe new cuff electrode enables rapid development of cost-effective functional stimulation devices targeting nerve bundles less than 1.0 mm in diameter. This allows for recording and modulation of a low-frequency current targeted within the peripheral nervous system.

Indexed as

CarbonGraphiteAnimalsBridged Bicyclo Compounds, HeterocyclicElectrodesElectrodes, ImplantedPolymersRatsRats, Sprague-DawleySootStereolithographyBridged Bicyclo Compounds, HeterocyclicCarbonGraphitepoly(3,4-ethylene dioxythiophene)PolymersSoot3D printingcuff electrodeelectrode contactimproved charge transfer capacityintrinsically conductive polymer

Identifiers

PMID35971860
PMCPMC9825949
OpenAlexW4292197782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.