ArticleNature microbiology2022
The microbiome of a bacterivorous marine choanoflagellate contains a resource-demanding obligate bacterial associate.
Article in Nature microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- Magnetoreception in a freshwater ciliate arises from endosymbiosis.Nature communications · 2026Article
- Self-carrier nanodrugs with dual antibacterial agents to overcome tobramycin resistance in multidrug-resistantBioactive materials · 2026Article
- Lineage-restricted genomic islands drive rhizosphere niche specialization inISME communications · 2026Article
- The evolutionary foundations of transcriptional regulation in animals.Nature reviews. Genetics · 2025Review
- Metagenomics of the MAST-3 stramenopile,Microbial genomics · 2025Article
- Comparative single-cell genomics of two uncultivatedmSphere · 2025Article
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- Genotype and culture condition effects on single-cell diatom microbiomes: enhanced detection of low-abundance taxa with CRISPR-Cas9.ISME communications · 2025Article
- From nets to networks: tools for deciphering phytoplankton metabolic interactions within communities and their global significance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- What choanoflagellates can teach us about symbiosis.PLoS biology · 2024Article
- Plankton community changes during the last 124 000 years in the subarctic Bering Sea derived from sedimentary ancient DNA.The ISME journal · 2024Article
- Disturbance frequency directs microbial community succession in marine biofilms exposed to shear.mSphere · 2023Article
- What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals.Animal cognition · 2023Review
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Authors and funding
13 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial predators such as choanoflagellates are key players in ocean food webs. Choanoflagellates, which are the closest unicellular relatives of animals, consume bacteria and also exhibit marked biological transitions triggered by bacterial compounds, yet their native microbiomes remain uncharacterized. Here we report the discovery of a ubiquitous, uncultured bacterial lineage we name Candidatus Comchoanobacterales ord. nov., related to the human pathogen Coxiella and physically associated with the uncultured marine choanoflagellate Bicosta minor. We analyse complete 'Comchoano' genomes acquired after sorting single Bicosta cells, finding signatures of obligate host-dependence, including reduction of pathways encoding glycolysis, membrane components, amino acids and B-vitamins. Comchoano encode the necessary apparatus to import energy and other compounds from the host, proteins for host-cell associations and a type IV secretion system closest to Coxiella's that is expressed in Pacific Ocean metatranscriptomes. Interactions between choanoflagellates and their microbiota could reshape the direction of energy and resource flow attributed to microbial predators, adding complexity and nuance to marine food webs.
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