Evidence map›Paper›PMID 35970913›Full record

ArticleNature communications2022

A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness.

Francesco Antonica, Lucia Santomaso, Davide Pernici, Linda Petrucci, Giuseppe Aiello, Alessandro Cutarelli, Luciano Conti, Alessandro Romanel, Evelina Miele, Toma Tebaldi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

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  20. Profiling Glioma Stem Cell Dynamics via 3D-Based Cell Cycle Reporter Assays.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Francesco AntonicaArmenise-Harvard Laboratory of Brain Cancer, Department CIBIO, University of Trento, 38123, Trento, Italy. francesco.antonica@unitn.it.ORCID http://orcid.org/0000-0001-9359-9689
Lucia SantomasoArmenise-Harvard Laboratory of Brain Cancer, Department CIBIO, University of Trento, 38123, Trento, Italy.
Davide PerniciArmenise-Harvard Laboratory of Brain Cancer, Department CIBIO, University of Trento, 38123, Trento, Italy.
Linda PetrucciArmenise-Harvard Laboratory of Brain Cancer, Department CIBIO, University of Trento, 38123, Trento, Italy.
Giuseppe AielloArmenise-Harvard Laboratory of Brain Cancer, Department CIBIO, University of Trento, 38123, Trento, Italy.
Alessandro CutarelliLaboratory of Stem Cell Biology, Department CIBIO, University of Trento, 38123, Trento, Italy.ORCID http://orcid.org/0000-0001-7270-1816
Luciano ContiLaboratory of Stem Cell Biology, Department CIBIO, University of Trento, 38123, Trento, Italy.ORCID http://orcid.org/0000-0002-2050-9846
Alessandro RomanelLaboratory of Bioinformatics and Computational Genomics, Department CIBIO, University of Trento, 38123, Trento, Italy.ORCID http://orcid.org/0000-0003-4855-8620
Evelina MieleDepartment of Paediatric Haematology/Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-4747-1032
Toma TebaldiLaboratory of RNA and Disease Data Science, Department CIBIO, University of Trento, 38123, Trento, Italy.ORCID http://orcid.org/0000-0002-0625-1631
Luca TiberiArmenise-Harvard Laboratory of Brain Cancer, Department CIBIO, University of Trento, 38123, Trento, Italy. luca.tiberi@unitn.it.ORCID http://orcid.org/0000-0002-5983-3782
University of Trento · ITBambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric and adult high-grade gliomas are the most common primary malignant brain tumors, with poor prognosis due to recurrence and tumor infiltration after therapy. Quiescent cells have been implicated in tumor recurrence and treatment resistance, but their direct visualization and targeting remain challenging, precluding their mechanistic study. Here, we identify a population of malignant cells expressing Prominin-1 in a non-proliferating state in pediatric high-grade glioma patients. Using a genetic tool to visualize and ablate quiescent cells in mouse brain cancer and human cancer organoids, we reveal their localization at both the core and the edge of the tumors, and we demonstrate that quiescent cells are involved in infiltration of brain cancer cells. Finally, we find that Harmine, a DYRK1A/B inhibitor, partially decreases the number of quiescent and infiltrating cancer cells. Our data point to a subpopulation of quiescent cells as partially responsible of tumor invasiveness, one of the major causes of brain cancer morbidity.

Indexed as

Brain NeoplasmsGliomaAdultAnimalsBrainCell DivisionChildHumansMiceNeoplasm Invasiveness

Identifiers

PMID35970913
PMCPMC9378633
OpenAlexW4291463612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.