ReviewNature reviews. Neuroscience2022
Replay, the default mode network and the cascaded memory systems model.
Review in Nature reviews. Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation.Scientific reports · 2024Trial
- Ictal Epileptogenic Network Differences in Posterior Cingulate Epilepsy Subtypes Based on SEEG.CNS neuroscience & therapeutics · 2026Article
- No evidence for the impact of mind wandering on recognition associative task: an on-line preregistered study.Psychological research · 2026Article
- A Brain-wide Neuronal Spiking and Behavioral Dataset for Working Memory-specific Activation and Reactivation in Mice.Neuroscience bulletin · 2026Article
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- The default mode network exhibits circuit-specific selective vulnerability despite widespread amyloid burden in an animal model of Alzheimer's disease.Nature communications · 2026Article
- Cognitive maps as a medium for thought.Trends in cognitive sciences · 2026Review
- Nightly changes in neural activity and auditory processing of song control neurons depend on melatonin.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Place field dynamics in retrosplenial cortex compared to hippocampus.Progress in neurobiology · 2026Article
- Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The default mode network: where spontaneous thought meets memory consolidation.Current opinion in behavioral sciences · 2026Article
- Exercise enhances hippocampal-cortical ripple interactions in the human brain.Brain communications · 2026Article
- Hippocampal connectivity predicting recognition and categorization abilities.Frontiers in cognition · 2026Article
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- Dynamically shifting from compositional to conjunctive brain representations supports cognitive task learning.Nature communications · 2025Article
- Hierarchical Replay of Multi-regional Sequential Spiking Associated with Working Memory.Neuroscience bulletin · 2025Article
- Neural variability in the default mode network compresses with increasing belief precision during Bayesian inference.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Noncanonical circuits, states, and computations of the hippocampus.Science (New York, N.Y.) · 2025Review
- Default mode network connectivity predicts individual differences in long-term forgetting: Evidence for storage degradation, not retrieval failure.PLoS computational biology · 2025Article
- Motifs of human high-frequency oscillations structure processing and memory of continuous audiovisual narratives.Science advances · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The spontaneous replay of patterns of activity related to past experiences and memories is a striking feature of brain activity, as is the coherent activation of sets of brain areas - particularly those comprising the default mode network (DMN) - during rest. We propose that these two phenomena are strongly intertwined and that their potential functions overlap. In the 'cascaded memory systems model' that we outline here, we hypothesize that the DMN forms the backbone for the propagation of replay, mediating interactions between the hippocampus and the neocortex that enable the consolidation of new memories. The DMN may also independently ignite replay cascades, which support reactivation of older memories or high-level semantic representations. We suggest that transient cortical activations, inducing long-range correlations across the neocortex, are a key mechanism supporting a hierarchy of representations that progresses from simple percepts to semantic representations of causes and, finally, to whole episodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.