ArticleMolecular microbiology2022
Preferential catabolism of l- vs d-serine by Proteus mirabilis contributes to pathogenesis and catheter-associated urinary tract infection.
Article in Molecular microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- Pangenome analysis ofAntimicrobial agents and chemotherapy · 2026Article
- Contribution of three tRNA modification enzymes toInfection and immunity · 2026Article
- Catabolism of serine enantiomers represses enterohemorrhagicProceedings of the National Academy of Sciences of the United States of America · 2026Article
- L-serine promotes pro-carcinogenic effects of colibactin-producingGut microbes · 2025Article
- Metatranscriptomics-based metabolic modeling of patient-specific urinary microbiome during infection.NPJ biofilms and microbiomes · 2025Article
- Metabolic interplay betweenmBio · 2024Article
- Identification and comparison of protein composition of biofilms in response to EGCG fromBiofilm · 2024Article
- Article
- Unveiling the hidden arsenal: new insights intoFrontiers in cellular and infection microbiology · 2024Review
- Metabolomics survey of uropathogenic bacteria in human urine.Frontiers in microbiology · 2024Article
- Differential Contribution of Hydrogen Metabolism toPathogens (Basel, Switzerland) · 2023Article
- Organ agar serves as physiologically relevant alternative forInfection and immunity · 2023Article
- New Insights into the Pathogenesis and Treatment of Urinary Tract Infections.Pathogens (Basel, Switzerland) · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Proteus mirabilis is a common cause of urinary tract infection, especially in catheterized individuals. Amino acids are the predominant nutrient for bacteria during growth in urine, and our prior studies identified several amino acid import and catabolism genes as fitness factors for P. mirabilis catheter-associated urinary tract infection (CAUTI), particularly those for d- and l-serine. In this study, we sought to determine the hierarchy of amino acid utilization by P. mirabilis and to examine the relative importance of d- vs l-serine catabolism for critical steps in CAUTI development and progression. Herein, we show that P. mirabilis preferentially catabolizes l-serine during growth in human urine, followed by d-serine, threonine, tyrosine, glutamine, tryptophan, and phenylalanine. Independently disrupting catabolism of either d- or l-serine has minimal impact on in vitro phenotypes while completely disrupting both pathways decreases motility, biofilm formation, and fitness due to perturbation of membrane potential and cell wall biosynthesis. In a mouse model of CAUTI, loss of either serine catabolism system decreased fitness, but disrupting l-serine catabolism caused a greater fitness defect than disrupting d-serine catabolism. We, therefore, conclude that the hierarchical utilization of amino acids may be a critical component of P. mirabilis colonization and pathogenesis within the urinary tract.
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