Evidence map›Paper›PMID 35970715›Full record

ArticleJournal of geriatric oncology2023

Resilience in older adults with cancer: A scoping literature review.

Thomas George, Farah Shah, Abhay Tiwari, Eutiquio Gutierrez, Jingran Ji, George A Kuchel, Harvey J Cohen, Mina S Sedrak

Registry-linked trialOpen access · greenAbstract readScoping Review
In one paragraph

Article in Journal of geriatric oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06953648 (Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06953648 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation (REMM-HIIT-HCT)

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2025 to 2030Enrolled126ConditionsHematopoietic Stem Cell Transplantation, Cardiorespiratory FitnessArmsHigh Intensity Interval Training
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Provocative testing in community dwelling older adults: a path to identify physical resilience.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. A scoping review of resilience in adults with cancer based on the NIH resilience concept model.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  13. Article
  14. Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Thomas GeorgeDepartment of Internal Medicine, NYC Health and Hospitals/Coney Island, Brooklyn, NY, USA.
Farah ShahDepartment of Internal Medicine, Harbor-UCLA Medical Center, Los Angeles, CA, USA.
Abhay TiwariDepartment of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, USA.
Eutiquio GutierrezDepartment of Internal Medicine, Harbor-UCLA Medical Center, Los Angeles, CA, USA.
Jingran JiDepartment of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, USA.
George A KuchelDepartment of Medicine, Division of Geriatric Medicine, University of Connecticut School of Medicine, Farmington, CT, USA; UConn Center for Aging, University of Connecticut Health, Farmington, CT, USA.
Harvey J CohenDepartment of Medicine, Geriatric Medicine Division, Duke University School of Medicine, Durham, NC, USA; Duke Center for the Study of Aging and Human Development Center, Duke University School of Medicine, Durham, NC, USA.
Mina S SedrakDepartment of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, USA; Center for Cancer and Aging, City of Hope, Duarte, CA, USA. Electronic address: msedrak@coh.org.
City of Hope · USHarbor–UCLA Medical Center · USConey Island Hospital · USDuke University · USUniversity of Connecticut · US

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Sarah B. Peskoe · 2006 to 2026
$24.6M
Oncology Research Career Development ProgramK12CA001727 · NCI · CITY OF HOPE NATIONAL MEDICAL CENTER · PI MORTIMER, JOANNE E. · 1992 to 2024
$14.6M
Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
Targeting Senescence to Improve Frailty in Older Cancer SurvivorsK76AG074918 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEDRAK, MINA S · 2022 to 2024
$729k
Using Senolytics to Improve Physical Function in Older Breast Cancer SurvivorsR21CA277660 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEDRAK, MINA S · 2023 to 2024
$422k
Improving Clinical Trial Participation of Older Adults with CancerR03AG064377 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SEDRAK, MINA S · 2019 to 2020
$260k
NCI NIH HHS K12 CA001727NCI NIH HHS R21 CA277660NIA NIH HHS K76 AG074918NIA NIH HHS P30 AG028716NIA NIH HHS P30 AG067988NIA NIH HHS R03 AG064377
6 · The paper itself

Abstract

introductionResilience, the ability to respond to stressors by maintaining or rapidly returning to normal homeostasis, serves as a new paradigm to improve the care of older adults. However, resilience research in oncology is nascent. We aimed to describe the current research landscape on physical, cognitive, and psychosocial resilience in older cancer patients. MATERIALS AND

methodsWe searched PubMed/MEDLINE from inception to January 28, 2022 for records with the terms "resilient OR resilience OR resiliency." We included studies that focused on persons over age 65 with cancer and assessed physical, cognitive, or psychological resilience. We excluded studies that did not report original data; did not have the full text available; assessed resilience on fewer than three time points; and published in non-English languages. Definitions and measures of resilience were extracted and categorized using qualitative analysis.

resultsOf 473 articles screened, we found 29 articles that met criteria for inclusion in our review. There was a high degree of heterogeneity in the definitions and measures of resilience. Resilience was defined as robustness/resistance to decline (n = 11), recovery from trauma/stressor (n = 7), and adaptive and proactive coping behaviors (n = 6). Ten papers did not define resilience. 21 studies utilized longitudinal analysis, five studies used randomized and nonrandomized control trials, and four studies assessed pre-post analysis. Stressors included cancer diagnosis (n = 18), chemotherapy (n = 3), radiation (n = 3), acute illness (n = 3), surgery (n = 2), and hematopoietic cell transplant (n = 1). DISCUSSION: Evidence for predictors and determinants of resilience in older adults with cancer is limited by the absence of standardized definitions and measurements. There is a fundamental need for a more precise definition, measures, and understanding of the physiologic mechanisms underlying the response to the physical, cognitive, and psychosocial stressors of cancer and its treatments.

Indexed as

Hematopoietic Stem Cell TransplantationNeoplasmsResilience, PsychologicalAdaptation, PsychologicalAgedHumansCancerCancer treatmentCognitive functionHealthy agingOlder adultsPhysical functionPsychological functionResilience

Identifiers

PMID35970715
PMCPMC10089682
OpenAlexW4290975778

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.