Evidence map›Paper›PMID 35970646›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2022

A comparison of outcomes after lung transplantation between European and North American centers.

Zhizhou Yang, Tsuyoshi Takahashi, Yuriko Terada, Bryan F Meyers, Benjamin D Kozower, G Alexander Patterson, Ruben G Nava, Ramsey R Hachem, Chad A Witt, Derek E Byers and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Post-lung transplant surveillance in 2026: current practice, variability, and the need for standardization.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Zhizhou YangDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
Tsuyoshi TakahashiDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri. Electronic address: tsuyoshi.takahashi@wustl.edu.
Yuriko TeradaDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
Bryan F MeyersDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
Benjamin D KozowerDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
G Alexander PattersonDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
Ruben G NavaDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
Ramsey R HachemDivision of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
Chad A WittDivision of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
Derek E ByersDivision of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
Hrishikesh S KulkarniDivision of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
Rodrigo Vazquez GuillametDivision of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
Yan YanDivision of Public Health Sciences, Washington University, St. Louis, Missouri.
Su-Hsin ChangDivision of Public Health Sciences, Washington University, St. Louis, Missouri.
Daniel KreiselDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
Varun PuriDivision of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.

Funding

Optimizing Donor Management in Lung TransplantationR01HL146856 · NHLBI · WASHINGTON UNIVERSITY · PI Ana Baumann Walker, Matthew Galen Hartwig · 2020 to 2026
$2.7M
NHLBI NIH HHS R01 HL146856
6 · The paper itself

Abstract

backgroundWith advancements in basic science and clinical medicine, lung transplantation (LT) has evolved rapidly over the last three decades. However, it is unclear if significant regional variations exist in long-term outcomes after LT.

methodsTo investigate potential differences, we performed a retrospective, comparative cohort analysis of adult patients undergoing deceased donor single or double LT in North America (NA) or Europe between January 2006 and December 2016. Data up to April 2019 were abstracted from the International Society for Heart and Lung Transplantation (ISHLT) Thoracic Organ Registry. We compared overall survival (OS) between North American and European LT centers in a propensity score matched analysis.

resultsIn 3,115 well-matched pairs, though 30-day survival was similar between groups (NA 96.2% vs Europe 95.4%, p = 0.116), 5-year survival was significantly higher in European patients (NA 60.1% vs Europe 70.3%, p < 0.001).

conclusionsThis survival difference persisted in a sensitivity analysis excluding Canadian patients. Prior observations suggest that these disparities are at least partly related to better access to care via universal healthcare models prevalent in Europe. Future studies are warranted to confirm our findings and explore other causal mechanisms. It is likely that potential solutions will require concerted efforts from healthcare providers and policymakers.

Indexed as

Heart-Lung TransplantationLung TransplantationAdultCanadaHumansRegistriesRetrospective StudiesSurvival RateISHLTlung transplantationoutcomes

Identifiers

PMID35970646
PMCPMC10305841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.