Evidence map›Paper›PMID 35970309›Full record

ArticleThe Journal of allergy and clinical immunology2022

Understanding racial disparities in childhood asthma using individual- and neighborhood-level risk factors.

Esteban Correa-Agudelo, Lili Ding, Andrew F Beck, Cole Brokamp, Mekibib Altaye, Robert S Kahn, Tesfaye B Mersha

Abstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Pediatric asthma population risk stratification using k-means clustering.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025
    Article
  7. Article
  8. Management of asthma exacerbations in pediatric emergency departments across the United States.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025
    Article
  9. Review
  10. Proximity to fast-food restaurants and pediatric asthma outcomes.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Article
  11. Social inequalities in childhood asthma.The World Allergy Organization journal · 2024
    Review
  12. Article
  13. Article
  14. The Role of Neighborhood Air Pollution in Disparate Racial and Ethnic Asthma Acute Care Use.American journal of respiratory and critical care medicine · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Examination of disparities in prehospital encounters for pediatric asthma exacerbations.Journal of the American College of Emergency Physicians open · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Esteban Correa-AgudeloDivisions of Asthma Research, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
Lili DingDivisions of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
Andrew F BeckDivisions of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio; Divisions of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
Cole BrokampDivisions of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
Mekibib AltayeDivisions of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
Robert S KahnDivisions of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
Tesfaye B MershaDivisions of Asthma Research, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio. Electronic address: tesfaye.mersha@cchmc.org.

Funding

Unraveling ancestry and environmental exposure interactions in childhood asthmaR01HL132344 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MERSHA, TESFAYE B. · 2016 to 2020
$3.4M
Epigenome-wide variations and socio-environmental exposures in African American asthmatic childrenR01HG011411 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI MERSHA, TESFAYE B. · 2021 to 2025
$3.4M
Genetic ancestry differences in IgE- mediated peanut allergy in African AmericansR21AI157363 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI ASSA'AD, AMAL HALIM, MERSHA, TESFAYE B. · 2021 to 2022
$437k
NHGRI NIH HHS R01 HG011411NHLBI NIH HHS R01 HL132344NIAID NIH HHS R21 AI157363
6 · The paper itself

Abstract

backgroundRacial disparities in childhood asthma outcomes result from a complex interplay of individual- and neighborhood-level factors.

objectivesWe sought to examine racial disparities in asthma-related emergency department (ED) visits between African American (AA) and European American (EA) children.

methodsThis is a retrospective study of patients younger than 18 years who visited the ED at Cincinnati Children's for asthma from 2009 to 2018. The outcome was number of ED visits during a year. We assessed 11 social, economic, and environmental variables. Mediation and mixed-effects analyses were used to assess relationships between race, mediators, and number of ED visits.

resultsA total of 31,114 children (46.1% AA, 53.9% EA) had 186,779 asthma-related ED visits. AA children had more visits per year than EA children (2.23 vs 2.15; P < .001). Medicaid insurance was associated with a 7% increase in rate of ED visits compared with commercial insurance (1.07; 95% CI, 1.03-1.1). Neighborhood socioeconomic deprivation was associated with an increased rate of ED visits in AA but not in EA children. Area-level particulate matter with diameter less than 2.5 μm, pollen, and outdoor mold were associated with an increased rate of ED visits for both AA and EA children (all P < .001). Associations between race and number of ED visits were mediated by insurance, area-level deprivation, particulate matter with diameter less than 2.5 μm, and outdoor mold (all P < .001), altogether accounting for 55% of the effect of race on ED visits. Race was not associated with number of ED visits (P = .796) after accounting for mediators.

conclusionsRacial disparities in asthma-related ED visits are mediated by social, economic, and environmental factors, which may be amenable to interventions aimed at improving outcomes and eliminating inequities.

Indexed as

Retrospective StudiesChildHumansRisk FactorsAsthmaelectronic health recordsenvironmental exposuremediation analysismixed-effects analysisracial disparities

Identifiers

PMID35970309
PMCPMC9887733

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.