ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2022
Multiaxial fields improve SABRE efficiency by preserving hydride order.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Robust Rapid Cellular Metabolite Sensing Using Benchtop NMR and SABRE-Hyperpolarized [1-Analytical chemistry · 2026Article
- EfficientJournal of magnetic resonance open · 2025Article
- Live magnetic observation of parahydrogen hyperpolarization dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Signal Amplification By Reversible Exchange (SABRE) and the heteronuclear variant, X-SABRE, increase the sensitivity of magnetic resonance techniques using order derived from reversible binding of para-hydrogen. One current limitation of SABRE is suboptimal polarization transfer over the lifetime of the complex. Here, we demonstrate a multiaxial low-field pulse sequence which allows optimal polarization build-up during a low-field "evolution" pulse, followed by a high-field "mixing" pulse which permits proton decoupling along an orthogonal axis. This preserves the singlet character of the hydrides while allowing exchange to replenish the ligands on the iridium catalyst. This strategy leads to a 2.5-fold improvement over continuous field SABRE SHEATH experimentally which was confirmed with numerical simulation.
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