Evidence map›Paper›PMID 35969900›Full record

ArticleCytokine2022

The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults.

Giuseppe Oliveto, Carolina Scagnolari, Federica Frasca, Leonardo Sorrentino, Luigi Matera, Raffaella Nenna, Agnese Viscido, Mirko Scordio, Laura Petrarca, Anna Maria Zicari and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytokine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Microglial activation and RAS signaling: a dual-edged sword in neuroinflammation.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Giuseppe OlivetoVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy. Electronic address: giuseppe.oliveto@uniroma1.it.
Carolina ScagnolariVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Federica FrascaVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Leonardo SorrentinoVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Luigi MateraDepartment of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
Raffaella NennaDepartment of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
Agnese ViscidoVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Mirko ScordioVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Laura PetrarcaDepartment of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
Anna Maria ZicariDepartment of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
Elio GentiliniDepartment of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy.
Gabriella D'EttorreDepartment of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy.
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy.
Fabio MidullaDepartment of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
Guido AntonelliVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Alessandra PierangeliVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes. A significant activation of dACE2 transcript was found, in SARS-CoV-2 positive adults either hospitalized or not, showing a positive correlation with ISG15; f-lACE2 expression was weakly activated and not ISG-related. We confirmed a specific activation of dACE2 transcript in nasopharyngeal cells, related to the mucosal IFN response.

Indexed as

Angiotensin-Converting Enzyme 2COVID-19AdultAntiviral AgentsHumansInterferonsPeptidyl-Dipeptidase AProtein IsoformsSARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2Antiviral AgentsInterferonsPeptidyl-Dipeptidase AProtein IsoformsACE2COVID-19deleted ACE2Interferon, ISG15SARS-CoV-2

Identifiers

PMID35969900
PMCPMC9365862
OpenAlexW4292676758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.