Evidence map›Paper›PMID 35969793›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

ThnL, a B12-dependent radical

Erica K Sinner, Rongfeng Li, Daniel R Marous, Craig A Townsend

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Biosynthesis of the Biphenomycin Family of Potent Antibiotics.Angewandte Chemie (International ed. in English) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. RadicalJournal of the American Chemical Society · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erica K SinnerDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0003-2417-9319
Rongfeng LiDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0001-8879-3241
Daniel R MarousDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0002-8161-3057
Craig A TownsendDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0003-2795-7585
Johns Hopkins University · US

Funding

Biosynthesis of Beta Lactam AntibioticsR01AI121072 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 2016 to 2025
$4.9M
The Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5M
NIAID NIH HHS R01 AI121072NIGMS NIH HHS T32 GM080189
6 · The paper itself

Abstract

Complex carbapenems are important clinical antibiotics used to treat recalcitrant infections. Their biosynthetic gene clusters contain three essential B

Indexed as

CarbapenemsIron-Sulfur ProteinsS-AdenosylmethionineVitamin B 12CarbonPantetheineSulfidesCarbapenemsCarbonIron-Sulfur ProteinsPantetheineS-AdenosylmethionineSulfidesVitamin B 12antibioticB12-dependent radical SAMcarbapenemthioether

Identifiers

PMID35969793
PMCPMC9407657
OpenAlexW4291804738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.