Evidence map›Paper›PMID 35969789›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Delta/Notch signaling in glia maintains motor nerve barrier function and synaptic transmission by controlling matrix metalloproteinase expression.

Mario R Calderon, Megumi Mori, Grant Kauwe, Jill Farnsworth, Suzana Ulian-Benitez, Elie Maksoud, Jordan Shore, A Pejmun Haghighi

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Plant pathogenic nematode exosomes remodel vector tracheae to enhance pathogen transmission.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Arsenic toxicity in theFrontiers in toxicology · 2025
    Article
  5. Article
  6. Review
  7. Glia as Functional Barriers and Signaling Intermediaries.Cold Spring Harbor perspectives in biology · 2024
    Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mario R CalderonBuck Institute for Research on Aging, Novato, CA 94945.
Megumi MoriBuck Institute for Research on Aging, Novato, CA 94945.ORCID 0000-0002-4810-5480
Grant KauweBuck Institute for Research on Aging, Novato, CA 94945.
Jill FarnsworthBuck Institute for Research on Aging, Novato, CA 94945.ORCID 0000-0001-7773-5740
Suzana Ulian-BenitezBuck Institute for Research on Aging, Novato, CA 94945.ORCID 0000-0002-3782-5319
Elie MaksoudBuck Institute for Research on Aging, Novato, CA 94945.
Jordan ShoreBuck Institute for Research on Aging, Novato, CA 94945.
A Pejmun HaghighiBuck Institute for Research on Aging, Novato, CA 94945.ORCID 0000-0002-4928-3609
Buck Institute for Research on Aging · USUniversity of Southern California · US

Funding

Retrograde Regulation of Synaptic Strength by Translational MechanismsR01NS082793 · NINDS · BUCK INSTITUTE FOR RESEARCH ON AGING · PI HAGHIGHI, ALI PEJMUN · 2013 to 2022
$4.9M
Proteostasis and metabolism in brain agingR01AG057353 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI HAGHIGHI, ALI PEJMUN, JASPER, HEINRICH · 2017 to 2021
$3.1M
NIA NIH HHS R01 AG057353NINDS NIH HHS R01 NS082793
6 · The paper itself

Abstract

While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling cues originating in barrier-forming cells participate in maintaining barrier function and influence synaptic activity. We have identified Delta/Notch signaling in subperineurial glia (SPG), a crucial glial type for

Indexed as

Drosophila ProteinsMatrix Metalloproteinase 1NeurogliaSynaptic TransmissionAnimalsDrosophila melanogasterExtracellular MatrixIntracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesMembrane ProteinsReceptors, NotchSignal Transductiondelta proteinDrosophila ProteinsIntracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesMatrix Metalloproteinase 1Membrane ProteinsN protein, DrosophilaReceptors, Notchblood–brain barrierDelta/Notch signalinggliametalloproteinasesynaptic function

Identifiers

PMID35969789
PMCPMC9407389
OpenAlexW4291804712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.