Evidence map›Paper›PMID 35969762›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Nodulisporic acid produces direct activation and positive allosteric modulation of AVR-14B, a glutamate-gated chloride channel from adult

Shivani Choudhary, Melanie Abongwa, Sudhanva S Kashyap, Saurabh Verma, Gunnar R Mair, Daniel Kulke, Richard J Martin, Alan P Robertson

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shivani ChoudharyDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
Melanie AbongwaDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
Sudhanva S KashyapDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
Saurabh VermaDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
Gunnar R MairDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
Daniel KulkeDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
Richard J MartinDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.ORCID 0000-0003-2422-1847
Alan P RobertsonDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.ORCID 0000-0002-7980-1139
Iowa State University · US

Funding

RESISTANCE &MODULATION OF LEVAMISOLE RECEPTOR CHANNELSR01AI047194 · NIAID · IOWA STATE UNIVERSITY · PI MARTIN, RICHARD JOHN · 2001 to 2021
$5.8M
Slo-1K channels, TRP-2 channels, emodepside and diethylcarbamazine in FilariaR01AI155413 · NIAID · IOWA STATE UNIVERSITY · PI Richard John Martin · 2020 to 2026
$2.7M
Cholinergic anthelmintics: Tachyphylaxis mechanisms and control in a parasitic nematode model,Brugia malayiR21AI173819 · NIAID · IOWA STATE UNIVERSITY · PI KASHYAP, SUDHANVA SRINIVAS · 2023 to 2024
$436k
Cholinergic receptors on the nematode pharynx: an unexploited drug targetR21AI092185 · NIAID · IOWA STATE UNIVERSITY · PI ROBERTSON, ALAN P · 2011 to 2012
$415k
Trafficking of parasitic nematode ion channelsR21AI125899 · NIAID · UNIVERSITY OF GEORGIA · PI WOLSTENHOLME, ADRIAN J · 2016 to 2017
$413k
NIAID NIH HHS R01 AI047194NIAID NIH HHS R01 AI155413NIAID NIH HHS R21 AI092185NIAID NIH HHS R21 AI125899NIAID NIH HHS R21 AI173819
6 · The paper itself

Abstract

Glutamate-gated chloride channels (GluCls) are unique to invertebrates and are targeted by macrocyclic lactones. In this study, we cloned an AVR-14B GluCl subunit from adult

Indexed as

Brugia malayiChloride ChannelsIndolesAnimalsGlutamic AcidIvermectinLigandsChloride Channelsglutamate-gated chloride channelsGlutamic AcidIndolesIvermectinLigandsnodulisporic acid AAVR-14BBrugia malayifilarial nematodeglutamate-gated chloride channelsnodulisporic acid

Identifiers

PMID35969762
PMCPMC9407656
OpenAlexW4291652196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.