Evidence map›Paper›PMID 35969739›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A photo-switchable assay system for dendrite degeneration and repair in

Han-Hsuan Liu, Chien-Hsiang Hsu, Lily Y Jan, Yuh-Nung Jan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. A photo-switchable assay system for dendrite degeneration and repair inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Han-Hsuan LiuDepartment of Physiology, University of California, San Francisco, CA 94143.
Chien-Hsiang HsuDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143.
Lily Y JanDepartment of Physiology, University of California, San Francisco, CA 94143.ORCID 0000-0003-3938-8498
Yuh-Nung JanDepartment of Physiology, University of California, San Francisco, CA 94143.ORCID 0000-0003-1367-6299
University of California, San Francisco · US

Funding

Dendrite morphogenesis, function and regenerationR35NS097227 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, YUH NUNG · 2017 to 2024
$5.1M
Howard Hughes Medical InstituteNINDS NIH HHS R35 NS097227
6 · The paper itself

Abstract

Neurodegeneration arising from aging, injury, or diseases has devastating health consequences. Whereas neuronal survival and axon degeneration have been studied extensively, much less is known about how neurodegeneration affects dendrites, in part due to the limited assay systems available. To develop an assay for dendrite degeneration and repair, we used photo-switchable caspase-3 (caspase-Light-Oxygen-Voltage-sensing [caspase-LOV]) in peripheral class 4 dendrite arborization (c4da) neurons to induce graded neurodegeneration by adjusting illumination duration during development and adulthood in

Indexed as

Drosophila melanogasterAnimalsCaspasesCytological TechniquesDendritesDrosophila ProteinsMiceNeuronsWallerian DegenerationCaspasesDrosophila Proteinsdendrite degenerationdendrite regenerationdendrite repairDrosophilaWallerian degeneration slow protein

Identifiers

PMID35969739
PMCPMC9407391
OpenAlexW4291804475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.