ArticlePloS one2022
Determinants of unsuccessful tuberculosis treatment outcome in Northern Red Sea region, Eritrea.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment outcomes and associated factors among persons with pulmonary tuberculosis in Morocco: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Trends and determinants of tuberculosis treatment outcomes among patients at Hargeisa tuberculosis hospital, Somaliland (2019-2024): a multi-year retrospective study.BMC infectious diseases · 2026Article
- Article
- Evaluating tuberculosis treatment outcomes in Haiti from 2018 to 2019: A competing risk analysis.IJID regions · 2024Article
- Tuberculosis treatment outcomes and associated factors among tuberculosis patients treated at healthcare facilities of Motta Town, Northwest Ethiopia: a five-year retrospective study.Scientific reports · 2024Article
- Tuberculosis Treatment Outcomes and Associated Factors in Benadir Somalia. A Multicenter Cohort Study.International journal of general medicine · 2024Article
- Determinants of unsuccessful tuberculosis treatment outcome in Southwest Ethiopia regional state public hospitals, 2022: a multi-center case control study.Frontiers in public health · 2024Article
- Predictive capabilities of baseline radiological findings for early and late disease outcomes within sensitive and multi-drug resistant tuberculosis cases.European journal of radiology open · 2023Article
- Article
- Prognostic values of geriatric nutrition risk index on elderly patients after spinal tuberculosis surgery.Frontiers in nutrition · 2023Article
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7 authors.
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Abstract
backgroundEritrea has achieved the global target (90%) for tuberculosis (TB) treatment success rate. Though, events of unsuccessful TB treatment outcomes (death, treatment failure, lost to follow up and not evaluated) could lead to further TB transmission and the development of resistant strains. Hence, factors related to these events should be explored and addressed. This study aims to fill the gap in evidence by identifying the determinants of unsuccessful TB treatment outcomes in Eritrea's Northern Red Sea region.
methodsA retrospective cohort study was conducted in Eritrea's Northern Red Sea region. Data collected using a data extraction tool was analyzed using Stata version 13. Frequencies, proportions, median and standard deviations were used to describe the data. Furthermore, univariable and multivariable logistic regression analysis were performed to determine the risk factors for unsuccessful TB treatment outcomes. Crude odds ratio (COR) and adjusted odds ratio (AOR) with their 95% confidence interval (CI) presented and p-value < 0.05 was considered statistically significant.
resultsAmong 1227 TB patients included in this study, 9.6% had unsuccessful TB treatment outcomes. In multivariable logistic regression analysis, TB cases 55-64 years old (AOR: 2.75[CI: 1.21-6.32], p = 0.016) and those ≥ 65 years old (AOR: 4.02[CI: 1.72-9.45], p = 0.001) had 2.7 and 4 times higher likelihood of unsuccessful TB treatment outcome respectively. In addition, HIV positive TB patients (AOR: 5.13[CI: 1.87-14.06], p = 0.002) were 5 times more likely to have unsuccessful TB treatment outcome. TB treatment in Ghindae Regional Referral Hospital (AOR: 5.01[2.61-9.61], p < 0.001), Massawa Hospital (AOR: 4.35[2.28-8.30], p< 0.001) and Nakfa Hospital (AOR: 2.53[1.15-5.53], p = 0.021) was associated with 5, 4 and 2.5 higher odds of unsuccessful TB treatment outcome respectively.
conclusionIn this setting, old age, HIV co-infection and health facility were the independent predictors of unsuccessful TB treatment outcome.
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