Evidence map›Paper›PMID 35969501›Full record

ArticleJournal of proteome research2022

Proteomic Characterization of Collagen-Based Animal Glues for Restoration.

Georgia Ntasi, Sara Sbriglia, Rossana Pitocchi, Roberto Vinciguerra, Chiara Melchiorre, Laura Dello Ioio, Giancarlo Fatigati, Emanuele Crisci, Ilaria Bonaduce, Andrea Carpentieri and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of proteome research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Georgia NtasiDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cinthia 21, 80126 Naples, Italy.
Sara SbrigliaDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cinthia 21, 80126 Naples, Italy.
Rossana PitocchiDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cinthia 21, 80126 Naples, Italy.ORCID 0000-0001-8327-1380
Roberto VinciguerraDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cinthia 21, 80126 Naples, Italy.
Chiara MelchiorreDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cinthia 21, 80126 Naples, Italy.
Laura Dello IoioDello Ioio Restauri, Vico Equense, 80069 Naples, Italy.
Giancarlo FatigatiDepartment of Humanities, University Suor Orsola Benincasa, via Santa Caterina da Siena 37, 80132, Naples, Italy.
Emanuele CrisciDepartment of Chemistry and Industrial Chemistry, University of Pisa, via Risorgimento 35, 56126 Pisa, Italy.
Ilaria BonaduceDepartment of Chemistry and Industrial Chemistry, University of Pisa, via Risorgimento 35, 56126 Pisa, Italy.ORCID 0000-0003-0346-8373
Andrea CarpentieriDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cinthia 21, 80126 Naples, Italy.ORCID 0000-0002-1944-5355
Gennaro MarinoDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cinthia 21, 80126 Naples, Italy.
Leila BiroloDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cinthia 21, 80126 Naples, Italy.ORCID 0000-0002-0915-7501
University of Naples Federico II · ITUniversità degli Studi Suor Orsola Benincasa · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animal glues are widely used in restoration as adhesives, binders, and consolidants for organic and inorganic materials. Their variable performances are intrinsically linked to the adhesive properties of collagen, which determine the chemical, physical, and mechanical properties of the glue. We have molecularly characterized the protein components of a range of homemade and commercial glues using mass spectrometry techniques. A shotgun proteomic analysis provided animal origin, even when blended, and allowed us to distinguish between hide and bone glue on the basis of the presence of collagen type III, which is abundant in connective skin/leather tissues and poorly synthetized in bones. Furthermore, chemical modifications, a consequence of the preparation protocols from the original animal tissue, were thoroughly evaluated. Deamidation, methionine oxidation, and backbone cleavage have been analyzed as major collagen modifications, demonstrating their variability among different glues and showing that, on average, bone glues are less deamidated than hide glues, but more fragmented, and mixed-collagen glues are overall less deamidated than pure glues. We believe that these data may be of general analytical interest in the characterization of collagen-based materials and may help restorers in the selection of the most appropriate materials to be used in conservation treatments.

Indexed as

CollagenProteomicsAnimalsCollagenanimal gluecollagendeamidationGC-MSLC-MSMSprotein agingprotein degradationprotein modificationproteomics

Identifiers

PMID35969501
PMCPMC9442796
OpenAlexW4291617788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.