Evidence map›Paper›PMID 35969334›Full record

ArticleJournal of autism and developmental disorders2023

Examining Treatment Outcomes Across Contexts: How Do Child Baseline Characteristics Impact Measurement of Treatment Response?

Rebecca Grzadzinski, Alapika Jatkar, Kevin Donovan, Kinh Truong, Alison Holbrook, Catherine Lord, So Hyun Kim

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca GrzadzinskiCarolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA.
Alapika JatkarCarolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA.
Kevin DonovanPenn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Kinh TruongGillings School of Global Public Health, Department of Biostatistics, Chapel Hill, USA.
Alison HolbrookThe Simons Foundation, New York, NY, USA.
Catherine LordSemel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, USA.
So Hyun KimSchool of Psychology, Korea University, Seoul, South Korea. Sok2015@med.cornell.edu.

Funding

Adaptive Interventions for Minimally Verbal Children with ASD in the CommunityR01HD073975 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASARI, CONNIE L. · 2012 to 2016
$13.0M
North Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0M
Postdoctoral Research in Neurodevelopmental DisordersT32HD040127 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT, Mark D Shen · 2001 to 2026
$8.5M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 2013 to 2019
$8.0M
Autism Speaks 9650NCATS NIH HHS KL2 TR002490NICHD NIH HHS R01 HD073975NICHD NIH HHS T32 HD040127NICHD NIH HHS U54 HD079124
6 · The paper itself

Abstract

The evaluation of the overlap between the ADOS BOSCC and Standard BOSCC as well as the exploration of child characteristics that may predict change are important steps in consolidating data-driven definitions of "improvement". Participants were seen between 2 and 5 times with Standard BOSCC and ADOS BOSCC observations over the course of early intervention trials (Grzadzinski et al. in J Autism Dev Disord 46:2464, 2016; Kim et al. in Autism 23:5, 2019). Results showed consistency between the Standard BOSCC and ADOS BOSCC, highlighting the utility of both as metrics of change and treatment outcome across contexts. Baseline characteristics may play a role in the tailoring of early intervention to maximize treatment outcome and may offer guidance when determining which outcome measures to use.

Indexed as

Autism Spectrum DisorderAutistic DisorderChildEarly Intervention, EducationalHumansOutcome Assessment, Health CareTreatment OutcomeAutism spectrum disorder (ASD)Brief Observation of Social Communication Change (BOSCC)Early interventionTreatment outcome

Identifiers

PMID35969334
PMCPMC9969996

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.