Evidence map›Paper›PMID 35969308›Full record

ArticleNeurotoxicity research2022

Neuroprotective Potential of Intranasally Delivered Sulforaphane-Loaded Iron Oxide Nanoparticles Against Cisplatin-Induced Neurotoxicity.

Ghadha Ibrahim Fouad, Sara A M El-Sayed, Mostafa Mabrouk, Kawkab A Ahmed, Hanan H Beherei

Open access · hybridAbstract read
In one paragraph

Article in Neurotoxicity research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Magnetic Hydrogels as a Treatment for Oncological Pathologies.Journal of functional biomaterials · 2025
    Review
  4. Review
  5. Berberine-loaded iron oxide nanoparticles alleviate cuprizone-induced astrocytic reactivity in a rat model of multiple sclerosis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ghadha Ibrahim FouadDepartment of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El-Bohouth St., Dokki, Cairo, 12622, Egypt. gi.fouad@nrc.sci.eg.ORCID http://orcid.org/0000-0003-3665-3153
Sara A M El-SayedRefractories, Ceramics and Building Materials Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Cairo, 12622, Egypt.
Mostafa MabroukRefractories, Ceramics and Building Materials Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Cairo, 12622, Egypt.ORCID http://orcid.org/0000-0003-3330-6762
Kawkab A AhmedPathology Department, Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt.ORCID http://orcid.org/0000-0001-7376-7411
Hanan H BehereiRefractories, Ceramics and Building Materials Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Cairo, 12622, Egypt.ORCID http://orcid.org/0000-0001-5885-2845
National Research Centre · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin (CIS) is a platinum-based chemotherapeutic drug that is widely used to treat cancer. However, its therapeutic efficiency is limited due to its potential to provoke neurotoxicity. Sulforaphane (SF) is a natural phytochemical that demonstrated several protective activities. Iron oxide nanoparticles (Fe

Indexed as

NanoparticlesNeuroprotective AgentsNeurotoxicity SyndromesAcetylcholinesteraseAnimalsCisplatinDrug CarriersGlutathioneIronIsothiocyanatesLipid PeroxidesMagnetic Iron Oxide NanoparticlesNitric OxideOxidative StressRatsSulfoxidesAcetylcholinesteraseCisplatinDrug CarriersGlutathioneIronIsothiocyanatesLipid PeroxidesNeuroprotective AgentsNitric OxidesulforaphaneSulfoxidesAcetylcholinesteraseCisplatinIntranasalIron oxide nanoparticlesNeurotoxicitySulforaphane

Identifiers

PMID35969308
PMCPMC9515146
OpenAlexW4291891551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.