Evidence map›Paper›PMID 35969296›Full record

ArticleGeroScience2023

Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT

Caglar Cosarderelioglu, Lolita S Nidadavolu, Claudene J George, Ruth Marx-Rattner, Laura Powell, Qian-Li Xue, Jing Tian, Esther S Oh, Luigi Ferrucci, Pervin Dincer and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Caglar CosardereliogluDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Lolita S NidadavoluDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Claudene J GeorgeDepartment of Medicine, Division of Geriatrics, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Ruth Marx-RattnerDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Laura PowellDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Qian-Li XueDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Jing TianDepartment of Biostatistics, Bloomberg School of Public Health, Baltimore, MD, USA.
Esther S OhDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Luigi FerrucciNational Institute On Aging, National Institutes of Health, Baltimore, MD, USA.
Pervin DincerDepartment of Medical Biology, Hacettepe University School of Medicine, Ankara, Turkey.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Jeremy D WalstonDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Peter M AbadirDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA. Pabadir1@jhu.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USHacettepe University · TRMontefiore Medical Center · USNational Institutes of Health · USRush University Medical Center · US

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Age Related Change in Mitochondrial Angiotensin System and Mitochondrial DeclineR01AG046441 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABADIR, PETER M. · 2014 to 2018
$2.3M
AGE RELATED CHANGE IN ANGIOTENSIN RECEPTORS AND ITS ROLE IN CHRONIC INFLAMMATIONK23AG035005 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABADIR, PETER M. · 2010 to 2014
$807k
Utility of Centrally Acting Angiotensin Converting Enzyme Inhibitors to slow the progression of DementiaK23AG062807 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GEORGE, CLAUDENE · 2020 to 2024
$772k
NIA NIH HHS K23 AG035005NIA NIH HHS K23 AG062807NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG046441
6 · The paper itself

Abstract

The reported primary dementia-protective benefits of angiotensin II type 1 receptor (AT

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAged, 80 and overAmyloid beta-PeptidesAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAngiotensinsBrainHumansInflammationUp-RegulationAmyloid beta-PeptidesAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAngiotensinsAlzheimer’s diseaseAngiotensin receptor blockerAT4RBrainInflammationOxidative stress

Identifiers

PMID35969296
PMCPMC9886717
OpenAlexW4291819706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.