Evidence map›Paper›PMID 35969175›Full record

ArticleJournal of surgical oncology2022

Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC).

Cristian D Valenzuela, Omeed Moaven, Rohin Gawdi, John A Stauffer, Nico R Del Piccolo, Tan To Cheung, Carlos U Corvera, Andrew D Wisneski, Charles Cha, Nima Pourhabibi Zarandi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Advantages of the Laparoscopic Approach for the Initial Operation in Patients who Underwent Repeat Hepatectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cristian D ValenzuelaDivision of Surgical Oncology, Comprehensive Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.ORCID http://orcid.org/0000-0002-8694-9174
Omeed MoavenDivision of Surgical Oncology, Comprehensive Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.ORCID http://orcid.org/0000-0002-0560-0457
Rohin GawdiDivision of Surgical Oncology, Comprehensive Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
John A StaufferDepartment of Surgical Oncology, Mayo Clinic in Florida, Jacksonville, Florida, USA.
Nico R Del PiccoloDepartment of Surgical Oncology, Mayo Clinic in Florida, Jacksonville, Florida, USA.
Tan To CheungDepartment of Surgery, University of Hong Kong, Hong Kong, China.
Carlos U CorveraDepartment of Hepatobiliary & Pancreatic Surgery, University of California San Francisco, San Francisco, California, USA.
Andrew D WisneskiDepartment of Hepatobiliary & Pancreatic Surgery, University of California San Francisco, San Francisco, California, USA.
Charles ChaDepartment of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.
Nima Pourhabibi ZarandiDivision of Surgical Oncology, Comprehensive Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
Justin DouradoDivision of Surgical Oncology, Comprehensive Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
Kathleen C PerryDivision of Surgical Oncology, Comprehensive Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
Gregory RussellDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Perry ShenDivision of Surgical Oncology, Comprehensive Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
NCI NIH HHS P30 CA012197Wake Forest University Comprehensive Cancer Center Biostatistics Shared Resource via NCI P30CA012197
6 · The paper itself

Abstract

backgroundResection of colorectal liver metastasis (CLM) is beneficial when feasible. However, the benefit of second hepatectomy for hepatic recurrence in CLM remains unclear.

methodsThe Colorectal Liver Operative Metastasis International Collaborative retrospectively examined 1004 CLM cases from 2000 to 2018 from a total of 953 patients. Hepatic recurrence after initial hepatectomy was identified in 218 patients. Kaplan-Meier analysis was performed for overall survival (OS) and recurrence-free survival (RFS). Propensity score matching (PSM) was performed to offset selection bias. Cox proportional-hazards regression was performed to identify risk factors associated with OS.

resultsA total of 51 patients underwent second hepatectomy. Unadjusted median OS was 60.1 months in repeat-hepatectomy versus 38.3 months in the single-hepatectomy group (p = 0.015). In the PSM population, median OS remained significantly better in the repeat-hepatectomy group (60.1 vs. 33.1 months; p = 0.0023); median RFS was 12.4 months for the repeat-hepatectomy group, versus 9.8 months in the single-hepatectomy group (p = 0.0050). Repeat hepatectomy was associated with lower risk of death (hazard ratio: 0.283; p = 0.000012). Obesity, tobacco use, and high intraoperative blood loss were associated with significant risk of death (p < 0.05).

conclusionIn CLM with hepatic recurrence, second hepatectomy was beneficial for OS. With PSM, the OS benefit of performing a second hepatectomy remained significant.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsDisease-Free SurvivalHepatectomyHumansNeoplasm Recurrence, LocalRetrospective Studiesadenocarcinomacolon cancerhepatic resectionpropensity score matchingrectal cancer

Identifiers

PMID35969175
PMCPMC9613625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.