ArticleACS applied materials & interfaces2022
Designing Biological Microsensors with Chiral Nematic Liquid Crystal Droplets.
Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Temperature-Tunable Heliconical and Ferroelectric Nematics for White Lasing.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Predator-Prey Behavior of Droplets Propelling Through Self-Generated Channels in Crystalline Surfactant Layers.Angewandte Chemie (International ed. in English) · 2025Article
- Quorum Sensing in Emulsion Droplet Swarms Driven by a Surfactant Competition System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Reconfigurable Droplet-Droplet Communication Mediated by Photochemical Marangoni Flows.Journal of the American Chemical Society · 2024Article
- Aquatic Functional Liquid Crystals: Design, Functionalization, and Molecular Simulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Tunable Reflection through Size Polydispersity of Chiral-Nematic Liquid Crystal Polymer Particles.Molecules (Basel, Switzerland) · 2023Article
- Heads or tails: investigating the effects of amphiphile features on the distortion of chiral nematic liquid crystal droplets.Journal of materials chemistry. C · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosensing using liquid crystals has a tremendous potential by coupling the high degree of sensitivity of their alignment to their surroundings with clear optical feedback. Many existing set-ups use birefringence of nematic liquid crystals, which severely limits straightforward and frugal implementation into a sensing platform due to the sophisticated optical set-ups required. In this work, we instead utilize chiral nematic liquid crystal microdroplets, which show strongly reflected structural color, as sensing platforms for surface active agents. We systematically quantify the optical response of closely related biological amphiphiles and find unique optical signatures for each species. We detect signatures across a wide range of concentrations (from micromolar to millimolar), with fast response times (from seconds to minutes). The striking optical response is a function of the adsorption of surfactants in a nonhomogeneous manner and the topology of the chiral nematic liquid crystal orientation at the interface requiring a scattering, multidomain structure. We show that the surface interactions, in particular, the surface packing density, to be a function of both headgroup and tail and thus unique to each surfactant species. We show lab-on-a-chip capability of our method by drying droplets in high-density two-dimensional arrays and simply hydrating the chip to detect dissolved analytes. Finally, we show proof-of-principle
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