Evidence map›Paper›PMID 35969138›Full record

ArticleBlood transfusion = Trasfusione del sangue2023

Prevalence of anti-tick-borne encephalitis virus (TBEV) antibodies in Swiss blood donors in 2014-2015.

Rahel Ackermann-Gäumann, Claudia Eyer, Michael Vock, Peter Gowland, Caroline Tinguely, Stephen L Leib, Mauro Bori, Andreas Buser, Stefano Fontana, Jutta Thierbach and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood transfusion = Trasfusione del sangue, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Rahel Ackermann-GäumannSpiez Laboratory, Federal Office for Civil Protection, Spiez, Switzerland.
Claudia EyerInterregional Blood Transfusion SRC, Bern, Switzerland.
Michael VockInstitute of Mathematical Statistics and Actuarial Science, University of Bern, Bern, Switzerland.
Peter GowlandInterregional Blood Transfusion SRC, Bern, Switzerland.
Caroline TinguelyInterregional Blood Transfusion SRC, Bern, Switzerland.
Stephen L LeibInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Mauro BoriBlood Transfusion Service SRC della Svizzera Italiana, Lugano, Switzerland.
Andreas BuserBlood Transfusion Service Beider Basel, Basel, Switzerland.
Stefano FontanaInterregional Blood Transfusion SRC, Bern, Switzerland.
Jutta ThierbachBlood Transfusion Service SRC Nordostschweiz, St. Gallen, Switzerland.
Tina WeingandBlood Transfusion Service SRC Zentralschweiz, Luzern, Switzerland.
Christoph NiederhauserInterregional Blood Transfusion SRC, Bern, Switzerland.
Swiss Red Cross · CHUniversity of Bern · CHSpiez Laboratory · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisease morbidity of tick-borne encephalitis (TBE) has been increasing over the last decades. Since the 1990s, however, no extensive seroprevalence studies on TBE in humans have been performed in Switzerland. Here we assessed the prevalence of anti-TBE virus (TBEV) antibodies among different groups of the Swiss blood donor population. MATERIALS AND

methodsThe study was carried out from July 2014 to January 2015. Blood donors participating in the study (n=9,328) were asked to fill in a questionnaire relating to vaccination against or infection with different flaviviruses, and blood samples were collected. All samples were screened for the presence of anti-TBEV IgG antibodies using ELISA testing. Seropositivity rates in different groups of blood donors were compared using Chi square tests with Bonferroni correction.

resultsIn 2014 and 2015, 24.6% of healthy Swiss blood donors indicated vaccination against TBE. Among vaccinated blood donors, antibody prevalence was significantly higher in younger (<40y: 85.3%) than older individuals (≥40 to <55y: 80.0%, ≥55y: 76.7%; p=0.005). In non-vaccinated individuals, antibody prevalence was significantly higher in younger (<40y: 10.0%) than older (≥40 to <55y: 4.0%, ≥55y: 3.9%; p<0.005), male (6.8%) than female (3.7%, p<0.0001), and blood donors from endemic (7.0%) than border (6.2%) or non-endemic regions (4.2%, p<0.001). Possible asymptomatic infection, as defined by positive IgG ELISA results in blood donors indicating no vaccination against TBEV, was found in 5.6%. DISCUSSION: Our data importantly complement the knowledge on TBEV vaccination rates and estimate the frequency of subclinical TBE in Switzerland.

Indexed as

Encephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneAntibodies, ViralBlood DonorsFemaleHumansImmunoglobulin GMalePrevalenceSeroepidemiologic StudiesSwitzerlandAntibodies, ViralImmunoglobulin G

Identifiers

PMID35969138
PMCPMC10072989
OpenAlexW4291923291

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.