Evidence map›Paper›PMID 35969070›Full record

ArticleAntimicrobial agents and chemotherapy2022

Invasive Group A Streptococcal Penicillin Binding Protein 2× Variants Associated with Reduced Susceptibility to β-Lactam Antibiotics in the United States, 2015-2021.

Sopio Chochua, Benjamin Metcalf, Zhongya Li, Saundra Mathis, Theresa Tran, Joy Rivers, Katherine E Fleming-Dutra, Yuan Li, Lesley McGee, Bernard Beall

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Identification ofAntimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. Evaluating the use of whole-genome sequencing and SangerJournal of medical microbiology · 2026
    Article
  4. Article
  5. Frontiers in medicine · 2026
    Article
  6. Article
  7. Article
  8. From Infection to Autoimmunity:Microorganisms · 2025
    Review
  9. Article
  10. The N-terminal ELRThe Journal of biological chemistry · 2025
    Article
  11. Review
  12. Regulation of erm(T) MLSnpj antimicrobials and resistance · 2024
    Article
  13. Article
  14. Clinical microbiology reviews · 2024
    Review
  15. Increasing Rate of FatalMicroorganisms · 2024
    Article
  16. Review
  17. Article
  18. [Research progress on the mechanism of -lactam resistance in group AZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sopio ChochuaRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.ORCID 0000-0001-8222-7353
Benjamin MetcalfRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Zhongya LiASRT Inc., Contractor to Respiratory Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Saundra MathisASRT Inc., Contractor to Respiratory Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Theresa TranASRT Inc., Contractor to Respiratory Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Joy RiversRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Katherine E Fleming-DutraRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Yuan LiRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Lesley McGeeRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Bernard BeallRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

All known group A streptococci [GAS] are susceptible to β-lactam antibiotics. We recently identified an invasive GAS (iGAS) variant (

Indexed as

Peptidyl TransferasesAgarAmoxicillinAmpicillinAnti-Bacterial Agentsbeta-Lactam Resistancebeta-LactamsLincosamidesMacrolidesMicrobial Sensitivity TestsMonobactamsPenicillin-Binding ProteinsPeptidoglycanPhylogenyStreptococcus pneumoniaeStreptococcus pyogenesAgarAmoxicillinAmpicillinAnti-Bacterial Agentsbeta-LactamsLincosamidesMacrolidesMonobactamsPenicillin-Binding ProteinsPeptidoglycanPeptidyl Transferasesamino substituted β-lactamsclinical susceptibilitygroup A streptococcal lineagesPBP2x catalytic sitepenicillin binding protein 2×transpeptidase domain

Identifiers

PMID35969070
PMCPMC9487518
OpenAlexW4291901135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.