Evidence map›Paper›PMID 35969051›Full record

ArticleJournal of visualized experiments : JoVE2022

A New Optokinetic Testing Method to Measure Rat Vision.

Faizah Ahmed, Deepthi S Rajendran Nair, Biju B Thomas

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Animal models for the evaluation of retinal stem cell therapies.Progress in retinal and eye research · 2025
    Review
  3. Article
  4. Article
  5. A visually guided swim assay for mouse models of human retinal disease recapitulates the multi-luminance mobility test in humans.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Faizah Ahmed *Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California.
Deepthi S Rajendran Nair *Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California.
Biju B ThomasRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California; USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California; biju.thomas@med.usc.edu.
University of Southern California · USSouthern California Eye Institute · US

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Integration and functionality of retinal organoid transplantsR01EY031834 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEILER, MAGDALENE J · 2021 to 2025
$3.0M
VRC: A Stem Cell-Based Treatment Strategy for Laser-Induced Permanent Retinal DamagesR01EY031144 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMAS, BIJU BLAVADY · 2019 to 2021
$751k
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY031144NEI NIH HHS R01 EY031834
6 · The paper itself

Abstract

Optokinetic nystagmus (OKN) is a reflexive eye movement initiated by the motion of visual stimuli in the field of vision. The head-tracking movement associated with OKN is commonly used as a measure of visual function in rodents. To record OKN responses in normal and experimental rats, a simple and inexpensive apparatus has been developed. This setup uses two tablet screens to display the OKN visual stimulus consisting of high contrast black and white stripes generated using the OKN Stripes Visualization Web Application, a freely available software. The rat is placed inside a clear Plexiglass holder that limits movement so that the rat's head continuously faces the OKN display screen. The position of the rat holder can be changed to adjust the distance between the rat and the display screen. A micro-camera positioned above the rat holder is used to record the rat's visual activities. These recordings can be used for quantitative assessments. Based on the presence or absence of clear head-tracking, the OKN responses at different spatial frequencies can be determined. The collected data demonstrates a novel technique for reliable measurement of visual acuity in normal and retinal degenerate rats.

Indexed as

Nystagmus, OptokineticVision, OcularAnimalsMovementRatsRetinaVisual Acuity

Identifiers

PMID35969051
PMCPMC10081576
OpenAlexW4288060403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.