Evidence map›Paper›PMID 35968876›Full record

SynthesisThe Journal of infectious diseases2022

A Systematic Literature Review of the Burden of Respiratory Syncytial Virus and Health Care Utilization Among United States Infants Younger Than 1 Year.

Mina Suh, Naimisha Movva, Lauren C Bylsma, Jon P Fryzek, Christopher B Nelson

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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  11. Multi-faceted analysis and prediction for the outbreak of pediatric respiratory syncytial virus.Journal of the American Medical Informatics Association : JAMIA · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mina SuhEpidStrategies, A Division of ToxStrategies, Rockville, Maryland, USA.ORCID 0000-0002-9557-4933
Naimisha MovvaEpidStrategies, A Division of ToxStrategies, Rockville, Maryland, USA.ORCID 0000-0001-9300-5473
Lauren C BylsmaEpidStrategies, A Division of ToxStrategies, Rockville, Maryland, USA.ORCID 0000-0002-3091-6090
Jon P FryzekEpidStrategies, A Division of ToxStrategies, Rockville, Maryland, USA.ORCID 0000-0003-4089-3846
Christopher B NelsonSanofi, Swiftwater, Pennsylvania, USA.ORCID 0000-0003-1046-7635
BioStrategies (United States) · USSanofi (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe burden and health care utilization (HCU) of respiratory syncytial virus (RSV) in US infants aged <1 year across health care settings are not well characterized.

methodsWe systematically reviewed studies of RSV and bronchiolitis published 2000-2021 (data years, 1979-2020). Outcomes included RSV hospitalization (RSVH)/bronchiolitis hospitalization rates, emergency department (ED)/outpatient (OP) visit rates, and intensive care unit (ICU) admissions or mechanical ventilation (MV) use among RSV-/bronchiolitis-hospitalized infants. Study quality was determined using standard tools.

resultsWe identified 141 good-/fair-quality studies. Five national studies reported annual average RSVH rates (range, 11.6 per 1000 per year among infants aged 6-11 months in 2006 to 50.1 per 1000 per year among infants aged 0-2 months in 1997). Two national studies provided RSVH rates by primary diagnosis for the entire study period (range, 22.0-22.7 per 1000 in 1997-1999 and 1997-2000, respectively). No national ED/OP data were available. Among 11 nonnational studies, RSVH rates varied due to differences in time, populations (eg, prematurity), and locations. One national study reported that RSVH infants with high-risk comorbidities had 5-times more MV use compared to non-high-risk infants in 1997-2012.

conclusionsSubstantial data variability was observed. Nationally representative studies are needed to elucidate RSV burden and HCU.

Indexed as

BronchiolitisRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsHumansInfantInfant, NewbornInfant, PrematurePalivizumabPatient Acceptance of Health CareUnited StatesPalivizumabemergency departmentinfantsintensive care unit admissionlower respiratory tract infectionmechanical ventilationoutpatientrespiratory syncytial virusrespiratory syncytial virus hospitalizationRSVsystematic literature review

Identifiers

PMID35968876
PMCPMC9377044
OpenAlexW4285208932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.