Evidence map›Paper›PMID 35968869›Full record

ArticleThe Journal of infectious diseases2022

Medically Attended Illness due to Respiratory Syncytial Virus Infection Among Infants Born in the United States Between 2016 and 2020.

Jason R Gantenberg, Robertus van Aalst, Nicole Zimmerman, Brendan Limone, Sandra S Chaves, William V La Via, Christopher B Nelson, Christopher Rizzo, David A Savitz, Andrew R Zullo

Erratum issuedAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jason R GantenbergDepartment of Health Services, Policy and Practice, Brown University School of Public Health, Providence, Rhode Island, USA.ORCID 0000-0002-8144-4273
Robertus van AalstDepartment of Health Services, Policy and Practice, Brown University School of Public Health, Providence, Rhode Island, USA.ORCID 0000-0003-3025-7811
Nicole ZimmermanIBM Watson Health, Cambridge, Massachusetts, USA.ORCID 0000-0001-5819-7844
Brendan LimoneIBM Watson Health, Cambridge, Massachusetts, USA.ORCID 0000-0002-5965-0038
Sandra S ChavesDepartment of Modeling, Epidemiology, and Data Science, Vaccines Medical Affairs, Sanofi, Lyon, France.ORCID 0000-0002-9453-7057
William V La ViaVaccines Medical Affairs, Sanofi, Swiftwater, Pennsylvania, USA.ORCID 0000-0002-3819-5670
Christopher B NelsonVaccines Medical Affairs, Sanofi, Swiftwater, Pennsylvania, USA.ORCID 0000-0003-1046-7635
Christopher RizzoVaccines Medical Affairs, Sanofi, Swiftwater, Pennsylvania, USA.ORCID 0000-0002-9828-6769
David A SavitzDepartment of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.ORCID 0000-0002-3475-4113
Andrew R ZulloDepartment of Health Services, Policy and Practice, Brown University School of Public Health, Providence, Rhode Island, USA.ORCID 0000-0003-1673-4570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is a leading cause of infant hospitalization in the United States. Preterm infants and those with select comorbidities are at highest risk of RSV-related complications. However, morbidity due to RSV infection is not confined to high-risk infants. We estimated the burden of medically attended (MA) RSV-associated lower respiratory tract infection (LRTI) among infants in the United States.

methodsWe analyzed commercial (MarketScan Commercial [MSC], Optum Clinformatics [OC]), and Medicaid (MarketScan Medicaid [MSM]) insurance claims data for infants born between April 2016 and February 2020. Using both specific and sensitive definitions of MA RSV LRTI, we estimated the burden of MA RSV LRTI during infants' first RSV season, stratified by gestational age, comorbidity status, and highest level of medical care associated with the MA RSV LRTI diagnosis.

resultsAccording to the specific definition 75.0% (MSC), 78.6% (MSM), and 79.6% (OC) of MA RSV LRTI events during infants' first RSV season occurred among term infants without known comorbidities.

conclusionsTerm infants without known comorbidities account for up to 80% of the MA RSV LRTI burden in the United States during infants' first RSV season. Future prevention efforts should consider all infants.

Indexed as

Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsFemaleHospitalizationHumansInfantInfant, NewbornInfant, PrematureUnited Statesburdeninfantsrespiratory syncytial virus

Identifiers

PMID35968869
PMCPMC9377038

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.