Evidence map›Paper›PMID 35968796›Full record

ArticleThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2024

Stem Cell Therapy for Repair of the Injured Brain: Five Principles.

Ruslan Rust, Christian Tackenberg

Abstract read
In one paragraph

Article in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. "Time Is Brain" - for Cell Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. The blood-brain barrier: a help and a hindrance.Brain : a journal of neurology · 2025
    Review
  7. Review
  8. Brain repair mechanisms after cell therapy for stroke.Brain : a journal of neurology · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ruslan RustInstitute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland.ORCID 0000-0003-3376-3453
Christian TackenbergInstitute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland.ORCID 0000-0002-0019-3055

Funding

Swiss National Science Foundation
6 · The paper itself

Abstract

Cell therapy holds great promise for regenerative treatment of disease. Despite recent breakthroughs in clinical research, applications of cell therapies to the injured brain have not yielded the desired results. We pinpoint current limitations and suggest five principles to advance stem cell therapies for brain regeneration. While we focus on cell therapy for stroke, all principles also apply for other brain diseases.

Indexed as

Stem Cell TransplantationStrokeBrainCell- and Tissue-Based TherapyHumansbrain injurycell therapyiPSCsNPCsregenerative therapystroke

Identifiers

PMID35968796
PMCPMC10822053

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.