ArticleFrontiers in neurology2022
Net water uptake, a neuroimaging marker of early brain edema, as a predictor of symptomatic intracranial hemorrhage after acute ischemic stroke.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Net water uptake as a predictive neuroimaging marker for acute ischemic stroke outcomes: a meta-analysis.European radiology · 2024Pooled it
- Review
- Autoregulation-Guided Blood Pressure Targets After Stroke Thrombectomy: Impact on Secondary Brain Injury and Neurologic Outcomes.Neurology · 2026Observational
- Net water uptake as a predictor of the development of high-density lesions after endovascular treatment.Neuroradiology · 2026Article
- Predictive value of net water uptake for early neurological deterioration after mechanical thrombectomy in acute ischemic stroke with large vessel occlusion.Frontiers in neurology · 2025Article
- Automated Prediction of Proximal Middle Cerebral Artery Occlusions in Noncontrast Brain Computed Tomography.Stroke · 2024Article
- Comparison of Cerebral Saturation and Brain Net Water Uptake After Moderate Traumatic Brain Injury.Advances in experimental medicine and biology · 2024Article
- Net water uptake within the ischemic penumbra predicts the presence of the midline shift in patients with acute ischemic stroke.Frontiers in neurology · 2023Article
- Clinical software for unsupervised automated net water uptake analysis predicts futile recanalization in acute ischemic stroke.Frontiers in neurologyArticle
- Defining Large Core Infarction: Comparing the Accuracy of Non-Contrast CT ASPECTS Versus CT Perfusion Core Volume.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: We hypothesized that quantitative net water uptake (NWU), a novel neuroimaging marker of early brain edema, can predict symptomatic intracranial hemorrhage (sICH) after acute ischemic stroke (AIS). Methods: We enrolled patients with AIS who completed admission multimodal computed tomography (CT) within 24 h after stroke onset. NWU within the ischemic core and penumbra was calculated based on admission CT, namely NWU-core and NWU-penumbra. sICH was defined as the presence of ICH in the infarct area within 7 days after stroke onset, accompanied by clinical deterioration. The predictive value of NWU-core and NWU-penumbra on sICH was evaluated by logistic regression analyses and the receiver operating characteristic (ROC) curve. A pure neuroimaging prediction model was built considering imaging markers, which has the potential to be automatically quantified with an artificial algorithm on image workstation. Results: 154 patients were included, of which 93 underwent mechanical thrombectomy (MT). The median time from symptom onset to admission CT was 262 min (interquartile range, 198-368). In patients with MT, NWU-penumbra (OR =1.442; 95% CI = 1.177-1.766; Conclusions: NWU-penumbra may have better predictive performance than NWU-core on sICH after MT. A pure imaging model showed potential value to automatically screen patients with sICH risk by image recognition, which may optimize treatment strategy.
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