ReviewFrontiers in neurology2022
EEG biomarkers for the diagnosis and treatment of infantile spasms.
Review in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Seizure Outcome After Intraoperative Electrocorticography-Tailored Epilepsy Surgery: A Systematic Review and Meta-Analysis.Neurology · 2024Pooled it
- Inter-rater reliability and clinical utility of the BASED score in infantile epileptic spasms syndrome.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- SinTransNet: an EEG-based deep learning framework for infantile epileptic spasms syndrome detection.BMC medical informatics and decision making · 2026Article
- Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase-amplitude coupling.Epilepsia open · 2026Article
- EEG functional connectivity as a marker of evolution from infantile epileptic spasms syndrome to Lennox-Gastaut syndrome.Epilepsia · 2026Article
- Electrophysiological readout of ACTH-related neuroendocrine-immunomodulatory treatment response in infantile epileptic spasms syndrome: suppression of scalp ripple propagation networks.Frontiers in immunology · 2026Article
- IESS-FusionNet: Physiologically Inspired EEG-EMG Fusion with Linear Recurrent Attention for Infantile Epileptic Spasms Syndrome Detection.Bioengineering (Basel, Switzerland) · 2025Article
- Distributed EEG source localization of hypsarrhythmia in west syndrome: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.BMC neurology · 2025Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Frontiers in EEG as a tool for the management of pediatric epilepsy: Past, present, and future.Epilepsia open · 2025Article
- Chaos to clarity: interpreting time series complexity metrics with an application to depression.Discover mental health · 2025Review
- Association Between Scalp High-Frequency Oscillations and Burden of Amplitudes and Epileptiform Discharges (BASED) Scores in Infantile Epileptic Spasms Syndrome.Biomolecules · 2025Article
- Computational EEG Analysis and Machine Learning: A New Frontier in Electroclinical Outcome Prediction for IESS.Indian journal of pediatrics · 2025Article
- Liquid Medication Dosing Errors: Comparison of a Ready-to-Use Vigabatrin Solution to Reconstituted Solutions of Vigabatrin Powder for Oral Solution.Advances in therapy · 2025Article
- Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures.Journal of neurodevelopmental disorders · 2025Article
- Clinical trials for Lennox-Gastaut syndrome: Challenges and priorities.Annals of clinical and translational neurology · 2024Review
- EEG-based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms.Epilepsia open · 2024Article
- Mean global field power is reduced in infantile epileptic spasms syndrome after response to vigabatrin.Frontiers in neurology · 2024Article
- High frequency oscillation network dynamics predict outcome in non-palliative epilepsy surgery.Brain communications · 2024Article
- A comprehensive wireless neurological and cardiopulmonary monitoring platform for pediatrics.PLOS digital health · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early diagnosis and treatment are critical for young children with infantile spasms (IS), as this maximizes the possibility of the best possible child-specific outcome. However, there are major barriers to achieving this, including high rates of misdiagnosis or failure to recognize the seizures, medication failure, and relapse. There are currently no validated tools to aid clinicians in assessing objective diagnostic criteria, predicting or measuring medication response, or predicting the likelihood of relapse. However, the pivotal role of EEG in the clinical management of IS has prompted many recent studies of potential EEG biomarkers of the disease. These include both visual EEG biomarkers based on human visual interpretation of the EEG and computational EEG biomarkers in which computers calculate quantitative features of the EEG. Here, we review the literature on both types of biomarkers, organized based on the application (diagnosis, treatment response, prediction, etc.). Visual biomarkers include the assessment of hypsarrhythmia, epileptiform discharges, fast oscillations, and the Burden of AmplitudeS and Epileptiform Discharges (BASED) score. Computational markers include EEG amplitude and power spectrum, entropy, functional connectivity, high frequency oscillations (HFOs), long-range temporal correlations, and phase-amplitude coupling. We also introduce each of the computational measures and provide representative examples. Finally, we highlight remaining gaps in the literature, describe practical guidelines for future biomarker discovery and validation studies, and discuss remaining roadblocks to clinical implementation, with the goal of facilitating future work in this critical area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.