Evidence map›Paper›PMID 35968052›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2022

Early Real-World Physician Experience with an Intracanalicular Dexamethasone Insert.

Cynthia Matossian, John D Stephens, Michelle K Rhee, Stephen E Smith, Parag A Majmudar, Subba Rao Gollamudi, Ravi H Patel, Maria E Rosselson, Aditi Bauskar, Alyssa Montieth and 5 more

Open access · goldAbstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Cynthia MatossianCM Associates, LLC, New Hope, PA, USA.ORCID 0000-0003-4119-5230
John D StephensTyson Eye, Fort Myers, FL, USA.
Michelle K RheeIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Stephen E SmithEye Associates, Fort Myers, FL, USA.
Parag A MajmudarChicago Cornea Consultants, Ltd., Chicago, IL, USA.
Subba Rao GollamudiEye Specialty Group, Memphis, TN, USA.ORCID 0000-0003-1261-8521
Ravi H PatelEye Associates of Central Texas, Round Rock, TX, USA.
Maria E RosselsonChicago Cornea Consultants, Ltd., Chicago, IL, USA.
Aditi BauskarOcular Therapeutix, Inc., Bedford, MA, USA.ORCID 0000-0001-7595-6267
Alyssa MontiethOcular Therapeutix, Inc., Bedford, MA, USA.
Fabiana Q SilvaOcular Therapeutix, Inc., Bedford, MA, USA.
Srilatha VantipalliOcular Therapeutix, Inc., Bedford, MA, USA.
Andrea GibsonOcular Therapeutix, Inc., Bedford, MA, USA.
Jamie Lynne MetzingerOcular Therapeutix, Inc., Bedford, MA, USA.
Michael H GoldsteinOcular Therapeutix, Inc., Bedford, MA, USA.
Chicago Cornea Consultants (United States) · USClinical Physiology Associates · USEye Care Associates · USIcahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To describe the early real-world experience of physicians with an intracanalicular dexamethasone insert (DEX) in patients undergoing cataract surgery and to capture the clinical impact of adopting this therapy. Patients and Methods: 23 United States sites including Ambulatory Surgical Center Setting (ASC) and Outpatient Clinical settings. Respondents were physicians who had early experience with DEX in cataract surgery patients. This was a Phase 4 experiential cross-sectional survey study comprised of 3 sequential online physician surveys. Descriptive statistics summarized the surveys' responses to determine the early impressions of the respondents. Results: Forty-two physicians completed surveys. On average, physicians reported feeling comfortable administering DEX after placing 3 inserts (mean 2.7; standard deviation 1.9). Most physicians (92%) were satisfied with DEX, and all physicians (100%) reported that DEX improved patient compliance. Most physicians (62.5%) indicated they would highly prefer DEX over traditional steroid eyedrops for the management of post-surgical inflammation and pain. Conclusion: The surveys exploring the early use of DEX suggest that DEX is a clinically effective treatment with a rapid initial learning curve and integrates well into clinical use. Physicians had a very positive early experience with DEX, including comfort with insertion and satisfaction. DEX shows promise as a primary treatment choice of physicians for ocular inflammation and pain following cataract surgery by offering patients a hands-free innovative therapy that delivers a preservative-free steroid to the ocular surface over approximately 30 days.

Indexed as

hands-free therapyintracanalicular dexamethasone insertocular inflammationocular painphacoemulsificationsustained-release drug delivery

Identifiers

PMID35968052
PMCPMC9365058
OpenAlexW4290018283

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.