Evidence map›Paper›PMID 35967925›Full record

ArticleComprehensive psychoneuroendocrinology2022

The effects of antimicrobials and lipopolysaccharide on acute immune responsivity in pubertal male and female CD1 mice.

Pasquale Esposito, Madeleine M Kearns, Kevin B Smith, Rajini Chandrasegaram, Anthony K Kadamani, Michelle Gandelman, Jacky Liang, Naghmeh Nikpoor, Thomas A Tompkins, Nafissa Ismail

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comprehensive psychoneuroendocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Microorganisms · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Pasquale EspositoNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
Madeleine M KearnsNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
Kevin B SmithNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
Rajini ChandrasegaramDepartment of Neuroscience, Faculty of Health Sciences, University of Cardiff, Cardiff, CF24 2FN, United Kingdom.
Anthony K KadamaniNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
Michelle GandelmanNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
Jacky LiangNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
Naghmeh NikpoorLallemand Health Solutions Inc, Montreal, Quebec, H1W 2N8, Canada.
Thomas A TompkinsLallemand Health Solutions Inc, Montreal, Quebec, H1W 2N8, Canada.
Nafissa IsmailNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
University of Ottawa · CALallemand (Canada) · CACardiff University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to stress during critical periods of development-such as puberty-is associated with long-term disruptions in brain function and neuro-immune responsivity. However, the mechanisms underlying the effect of stress on the pubertal neuro-immune response has yet to be elucidated. Therefore, the objective of the current study was to investigate the effect antimicrobial and lipopolysaccharide (LPS) treatments on acute immune responsivity in pubertal male and female mice. Moreover, the potential for probiotic supplementation to mitigate these effects was also examined. 240 male and female CD1 mice were treated with one week of antimicrobial treatment (mixed antimicrobials or water) and probiotic treatment (

Indexed as

InflammationLPSMicrobiomeProbioticsPubertySex differences

Identifiers

PMID35967925
PMCPMC9363646
OpenAlexW4282944690

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.