Evidence map›Paper›PMID 35967846›Full record

ArticleFrontiers in cellular and infection microbiology2022

Therapeutic effect of fecal microbiota transplantation on chronic unpredictable mild stress-induced depression.

Ting Cai, Shao-Peng Zheng, Xiao Shi, Ling-Zhi Yuan, Hai Hu, Bai Zhou, Shi-Lang Xiao, Fen Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ting CaiDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Shao-Peng ZhengDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Xiao ShiDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Ling-Zhi YuanDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Hai HuDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha, China.
Bai ZhouDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Shi-Lang XiaoDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Fen WangDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: Depression is a complex neuropsychiatric disease with extensive morbidity. Its pathogenesis remains unclear, and it is associated with extremely low rates of cure and complete remission. It is vital to study the pathogenesis of depression to develop effective treatments. This study aimed to explore the therapeutic effects and mechanisms of fecal microbiota transplantation (FMT) for the treatment of depression in rats. Methods: Thirty Sprague-Dawley (SD) rats were randomly divided into three groups: control, chronic unpredictable mild stress (CUMS) to model depression, and CUMS+FMT. For the CUMS and CUMS+FMT groups, after CUMS intervention (four weeks), the rats were given normal saline or FMT (once/week for three weeks), respectively. Behavior, colonic motility, 16S rDNA amplicon sequencing, and untargeted metabolomics on fecal samples were compared between the three rat groups. The following markers were analyzed: 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), and brain-derived neurotrophic factor (BDNF) levels in the hippocampus; glucagon-like peptide 1 (GLP-1), lipopolysaccharide (LPS), and interleukin (IL)-6 levels in the serum; and GLP-1, GLP-1 receptor (GLP-1R), and serotonin 4 receptor (5-HT Results: FMT improved symptoms of depression and colonic motility in rats exposed to CUMS. The expression levels of 5-HT, GABA, BDNF, and other biochemical indices, significantly differed among the three groups. Meanwhile, the intestinal microbiota in the CUMS+FMT group was more similar to that of the control group with a total of 13 different fecal metabolites. Conclusion: FMT exerted antidepressant effects on CUMS-induced depression in rats, and the mechanism involved various neurotransmitters, inflammatory factors, neurotrophic factors, and glucagon-like peptides.

Indexed as

DepressionFecal Microbiota TransplantationAnimalsBrain-Derived Neurotrophic Factorgamma-Aminobutyric AcidGlucagon-Like Peptide 1RatsRats, Sprague-DawleySerotoninStress, PsychologicalBrain-Derived Neurotrophic Factorgamma-Aminobutyric AcidGlucagon-Like Peptide 1Serotonindepressionfecal microbiota transplantationgastrointestinal mobilityintestinal microflorametabolites

Identifiers

PMID35967846
PMCPMC9366333
OpenAlexW4288080486

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.