SynthesisFrontiers in nutrition2022
Association between vitamins and risk of brain tumors: A systematic review and dose-response meta-analysis of observational studies.
Synthesis in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Review
- Causal Link of Seven Trace Elements and Eight Nutrients With Meningioma: A Bidirectional Two-Sample Mendelian Randomization Analysis.Brain and behavior · 2025Article
- Review
- The Efficacy of Dietary Intake, Supplementation, and Blood Concentrations of Carotenoids in Cancer Prevention: Insights from an Umbrella Meta-Analysis.Foods (Basel, Switzerland) · 2024Review
- Association between the dietary inflammatory index and all-cause mortality in the U.S. cancer survivors: A prospective cohort study using the National Health and Nutrition Examination Survey database.Preventive medicine reports · 2024Article
- Chinese Dietary Indices and Glioma: New Insights of a Case-Control Study in the Chinese Population.Nutrients · 2023Article
- Dietary B vitamins and glioma: A case-control study based on Chinese population.Frontiers in nutrition · 2023Article
- Association between dietary minerals and glioma: A case-control study based on Chinese population.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Brain tumor is one of the important causes of cancer mortality, and the prognosis is poor. Therefore, early prevention of brain tumors is the key to reducing mortality due to brain tumors. Objective: This review aims to quantitatively evaluate the association between vitamins and brain tumors by meta-analysis. Methods: We searched articles on PubMed, Cochrane Library, Web of Science, and Embase databases from inception to 19 December 2021. According to heterogeneity, the fixed-effects model or random-effects model was selected to obtain the relative risk of the merger. Based on the methods described by Greenland and Longnecker, we explored the dose-response relationship between vitamins and the risk of brain tumors. Subgroup analysis, sensitivity analysis, and publication bias were also used for the analysis. Results: The study reviewed 23 articles, including 1,347,426 controls and 6,449 brain tumor patients. This study included vitamin intake and circulating concentration. For intake, it mainly included vitamin A, vitamin B, vitamin C, vitamin E, β-carotene, and folate. For circulating concentrations, it mainly included vitamin E and vitamin D in the serum (25-hydroxyvitamin D and α-tocopherol). For vitamin intake, compared with the lowest intakes, the highest intakes of vitamin C (RR = 0.81, 95%CI:0.66-0.99, Conclusion: Our analysis suggests that the intake of vitamin C, β-carotene, and folate can reduce the risk of brain tumors, while high serum α-tocopherol concentration also has a protective effect on brain tumors. Therefore, vitamins may provide new ideas for the prevention of brain tumors. Systematic Review Registration: PROSPERO, identifier CRD42022300683.
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