Evidence map›Paper›PMID 35967726›Full record

ArticleFrontiers in psychology2022

Bias in measurement of autism symptoms by spoken language level and non-verbal mental age in minimally verbal children with neurodevelopmental disorders.

Shuting Zheng, Aaron Kaat, Cristan Farmer, Audrey Thurm, Catherine A Burrows, Stephen Kanne, Stelios Georgiades, Amy Esler, Catherine Lord, Nicole Takahashi and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 2 countries.

Shuting ZhengDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Aaron KaatFeinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Cristan FarmerNeurodevelopmental and Behavioral Phenotyping Service, National Institute of Mental Health, Bethesda, MD, United States.
Audrey ThurmNeurodevelopmental and Behavioral Phenotyping Service, National Institute of Mental Health, Bethesda, MD, United States.
Catherine A BurrowsDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
Stephen KanneCenter for Autism and the Developing Brain, Weill Cornell Medical College, White Plains, NY, United States.
Stelios GeorgiadesOfford Centre for Child Studies, McMaster University, Hamilton, ON, Canada.
Amy EslerMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States.
Catherine LordUCLA Semel Institute for Neuroscience & Human Behavior, Center for Autism Research and Treatment, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Nicole TakahashiThompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, Columbia, MO, United States.
Kerri P NowellThompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, Columbia, MO, United States.
Elizabeth WillDepartment of Psychology, University of South Carolina, Columbia, SC, United States.
Jane RobertsDepartment of Psychology, University of South Carolina, Columbia, SC, United States.
Somer L BishopDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
National Institute of Mental Health · USUniversity of California, San Francisco · USUniversity of Minnesota · USUniversity of South Carolina · USCenter for Autism and Related Disorders · USCornell University · USMcMaster University · CANorthwestern University · USUniversity of Missouri · USUniversity of Missouri Health System · US

Funding

Univ of Minnesota Buidling Interdisciplinary Research Careers in Women's HealthK12HD055887 · NICHD · UNIVERSITY OF MINNESOTA · PI ALLEN, SHARON S, BERGE, JERICA M · 2007 to 2023
$8.6M
Development of a standardized measure of social-communication abilities for children with neurodevelopmental disordersR01HD093012 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BISHOP, SOMER L. · 2017 to 2022
$3.2M
University of MN Building Interdisciplinary Research Careers in Women's HealthK12AR084223 · NIAMS · UNIVERSITY OF MINNESOTA · PI SHARON S ALLEN, Kristen Patricia Mark · 2023 to 2026
$2.2M
NIAMS NIH HHS K12 AR084223NICHD NIH HHS K12 HD055887NICHD NIH HHS R01 HD093012
6 · The paper itself

Abstract

Increasing numbers of children with known genetic conditions and/or intellectual disability are referred for evaluation of autism spectrum disorder (ASD), highlighting the need to refine autism symptom measures to facilitate differential diagnoses in children with cognitive and language impairments. Previous studies have reported decreased specificity of ASD screening and diagnostic measures in children with intellectual disability. However, little is known about how cognitive and language abilities impact the measurement of specific ASD symptoms in this group. We aggregated a large sample of young children (N = 1196; aged 31-119 months) to examine measurement invariance of ASD symptoms among minimally verbal children within the context of the Autism Diagnostic Observation Schedule (ADOS) Module 1. Using confirmatory factor analysis (CFA) and moderated non-linear factor analysis (MNLFA), we examined how discrete behaviors were differentially associated with the latent symptom domains of social communication impairments (SCI) and restricted and repetitive behaviors (RRB) across spoken language levels and non-verbal mental age groupings. While the two-factor structure of SCI and RRB held consistently across language and cognitive levels, only partial invariance was observed for both ASD symptom domains of SCI and RRB. Specifically, four out of the 15 SCI items and one out of the three RRB items examined showed differential item functioning between children with "Few to No Words" and those with "Some Words"; and one SCI item and one RRB item showed differential item functioning across non-verbal mental age groups. Moreover, even after adjusting for the differential item functioning to reduce measurement bias across groups, there were still differences in ASD symptom domain scores across spoken language levels. These findings further underscore the influence of spoken language level on measurement of ASD symptoms and the importance of measuring ASD symptoms within refined spoken language levels, even among those with minimal verbal abilities.

Indexed as

ADOSautism symptomslanguage levelmeasurement invariancenonverbal mental age

Identifiers

PMID35967726
PMCPMC9372407
OpenAlexW4288489473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.