Evidence map›Paper›PMID 35967466›Full record

ArticleMolecular & cellular toxicology2022

Intestine epithelial cell-derived extracellular vesicles alleviate inflammation induced by

Shuangshuang Wan, Guangzhong Song, Hui Hu, Yaqing Xu, Peng Zeng, Shan Lin, Jun Yang, Jinqin Jiang, Xiaojun Song, Yongneng Luo and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  5. Antioxidants (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shuangshuang WanSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Guangzhong SongSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Hui HuSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Yaqing XuSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Peng ZengSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Shan LinSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Jun YangSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Jinqin JiangSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Xiaojun SongCentre of Laboratory Medicine, People's Hospital of Hangzhou Medical College, Zhejiang Provincial People's Hospital, Hangzhou, 310014 Zhejiang China.
Yongneng LuoSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.
Dazhi JinSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, No. 481 Binwen Rd., Hangzhou, 310053 Zhejiang China.ORCID 0000-0002-2613-7844
Hangzhou Medical College · CNBlood Center of Zhejiang Province · CNZhejiang Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objectives: The protective effect of I-Evs against Results: Mouse I-Evs with mean diameter ranging from 100 to 200 nm and a density of 1.09-1.17 g/mL were obtained and confirmed containing the Ev-associated specific surface markers CD63 and TSG101 as well as high level of TGF-β1. In MC38 cells, I-Evs were able to decrease the gene expression of IL-6, TNF-α, IL-1β, and IL-22 induced by Conclusion: For the first time, our study demonstrated that I-Evs originated from intestine epithelial cells can alleviate inflammation induced by

Indexed as

Clostridioides difficileExtracellular vesiclesImmunotherapyInflammatory cytokinesRegulatory T cellsTcdBTGF-β1

Identifiers

PMID35967466
PMCPMC9362614
OpenAlexW4288685422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.