Evidence map›Paper›PMID 35967428›Full record

ArticleFrontiers in immunology2022

Impaired antigen-specific B-cell responses after Influenza vaccination in kidney transplant recipients receiving co-stimulation blockade with Belatacept.

Vincent Pernin, Maria Meneghini, Alba Torija, Thomas Jouve, Arnaud Del Bello, Iván Sanz-Muñoz, Jose Maria Eiros, Laura Donadeu, Carol Polo, Francisco Morandeira and 7 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Vincent PerninKidney Transplant Unit, Nephrology Department. Montpellier University Hospital, Montpellier, France.
Maria MeneghiniKidney transplant Unit. Nephrology Department. Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Alba TorijaLaboratoryof Nephrology and Transplantation. Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Thomas JouveLaboratoryof Nephrology and Transplantation. Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Arnaud Del BelloCentro Nacional de Gripe de Valladolid, Universidad de Valladolid, Valladolid, Spain.
Iván Sanz-MuñozCentro Nacional de Gripe, Valladolid Universidad de Valladolid, Valladolid, Spain.
Jose Maria EirosDepartment of Microbiology and Parasitology, Rio Hortega University Hospital, University of Valladolid, Valladolid, Spain.
Laura DonadeuLaboratoryof Nephrology and Transplantation. Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Carol PoloKidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain.
Francisco MorandeiraImmunology Department, Bellvitge University Hospital, Barcelona, Spain.
Sergio NavarroImmunology Department, Bellvitge University Hospital, Barcelona, Spain.
Cristina MasuetDepartment of Preventive Medicine, Bellvitge University Hospital, Barcelona, Spain.
Alexandre FavàKidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain.
Moglie LeQuintrecKidney Transplant Unit, Nephrology Department. Montpellier University Hospital, Montpellier, France.
Nassim KamarKidney transplant Unit, Nephrology Department. Grenoble University Hospital, Grenoble, France.
Elena CrespoLaboratoryof Nephrology and Transplantation. Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Oriol BestardKidney transplant Unit. Nephrology Department. Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Bellvitge University Hospital · ESVall d'Hebron Institut de Recerca · ESUniversidad de Valladolid · ESCentre Hospitalier Universitaire de Grenoble · FRCentre Hospitalier Universitaire de Montpellier · FRUniversité de Montpellier · FRUniversité Grenoble Alpes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging data suggest that costimulation blockade with belatacept effectively controls humoral alloimmune responses. However, whether this effect may be deleterious for protective anti-infectious immunity remains poorly understood. We performed a mechanistic exploratory study in 23 kidney transplant recipients receiving either the calcineurin-inhibitor tacrolimus (Tac, n=14) or belatacept (n=9) evaluating different cellular immune responses after influenza vaccination such as activated T follicular Helper (Tfh), plasmablasts and H1N1 hemagglutinin (HA)-specific memory B cells (HA

Indexed as

Influenza A Virus, H1N1 SubtypeKidney TransplantationAbataceptHumansTransplant RecipientsVaccinationAbataceptcalcineurin inhibitorsco-stimulation blockadeinfluenza vaccinationkidney transplantationmemory B cellsT follicular helper (Tfh) cell

Identifiers

PMID35967428
PMCPMC9374104
OpenAlexW4288695399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.