Evidence map›Paper›PMID 35967392›Full record

ArticleFrontiers in immunology2022

A recombinant murine-like rotavirus with Nano-Luciferase expression reveals tissue tropism, replication dynamics, and virus transmission.

Yinxing Zhu, Liliana Sánchez-Tacuba, Gaopeng Hou, Takahiro Kawagishi, Ningguo Feng, Harry B Greenberg, Siyuan Ding

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  12. Mucosal and systemic neutralizing antibodies to norovirus induced in infant mice orally inoculated with recombinant rotaviruses.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Review
  15. Gut microbes
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yinxing ZhuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States.
Liliana Sánchez-TacubaVeterans Affairs (VA) Palo Alto Health Care System, Department of Veterans Affairs, Palo Alto, CA, United States.
Gaopeng HouDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States.
Takahiro KawagishiVeterans Affairs (VA) Palo Alto Health Care System, Department of Veterans Affairs, Palo Alto, CA, United States.
Ningguo FengVeterans Affairs (VA) Palo Alto Health Care System, Department of Veterans Affairs, Palo Alto, CA, United States.
Harry B GreenbergVeterans Affairs (VA) Palo Alto Health Care System, Department of Veterans Affairs, Palo Alto, CA, United States.
Siyuan DingDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States.
Washington University in St. Louis · USStanford Medicine · USVA Palo Alto Health Care System · US

Funding

Stanford/UNC Biomimetic U19 Research CenterU19AI116484 · NIAID · STANFORD UNIVERSITY · PI AMIEVA, MANUEL R, KUO, CALVIN J · 2015 to 2025
$13.5M
Regulation of Rotavirus Replication, Virulence, and Host Range Restriction by the Innate Immune SystemR01AI125249 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GREENBERG, HARRY BERNARD · 2017 to 2021
$2.1M
Interferon-Stimulated Gene Inhibition of Rotavirus Replication and Viral AntagonismR01AI150796 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2024
$2.0M
Mechanisms of Gastrointestinal COVID-19R56AI167285 · NIAID · WASHINGTON UNIVERSITY · PI CIORBA, MATTHEW AARON, DING, SIYUAN · 2022 to 2022
$304k
Rotavirus: Studies of the Effectors and Mechanisms of Heterotypic Humoral Immunity in Human Intestinal Epithelial CellsI01BX000158 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI GREENBERG, HARRY BERNARD · 2011 to 2022
–
BLRD VA I01 BX000158NIAID NIH HHS R01 AI125249NIAID NIH HHS R01 AI150796NIAID NIH HHS R56 AI167285NIAID NIH HHS U19 AI116484
6 · The paper itself

Abstract

Rotaviruses (RVs) are one of the main causes of severe gastroenteritis, diarrhea, and death in children and young animals. While suckling mice prove to be highly useful small animal models of RV infection and pathogenesis, direct visualization tools are lacking to track the temporal dynamics of RV replication and transmissibility

Indexed as

RotavirusRotavirus InfectionsAnimalsDiarrheaMiceMice, KnockoutTropismin vivo imaging systemNano-luciferaserotavirustissue tropismtransmission

Identifiers

PMID35967392
PMCPMC9372724
OpenAlexW4288535137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.