Evidence map›Paper›PMID 35967363›Full record

ReviewFrontiers in immunology2022

Balancing B cell responses to the allograft: implications for vaccination.

Clarkson Crane, Lauren Loop, Christine Anterasian, Bob Geng, Elizabeth Ingulli

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Unlocking Transplant Tolerance with Biomaterials.Advanced healthcare materials · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clarkson CraneDepartment of Pediatrics, Division of Pediatric Nephrology, University of California at San Diego and Rady Children's Hospital, San Diego, CA, United States.
Lauren LoopDepartment of Pediatrics, Division of Allergy and Immunology, University of California at San Diego and Rady Children's Hospital, San Diego, CA, United States.
Christine AnterasianDepartment of Pediatrics, Division of Allergy and Immunology, University of California at San Diego and Rady Children's Hospital, San Diego, CA, United States.
Bob GengDepartment of Pediatrics, Division of Allergy and Immunology, University of California at San Diego and Rady Children's Hospital, San Diego, CA, United States.
Elizabeth IngulliDepartment of Pediatrics, Division of Pediatric Nephrology, University of California at San Diego and Rady Children's Hospital, San Diego, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Balancing enough immunosuppression to prevent allograft rejection and yet maintaining an intact immune system to respond to vaccinations, eliminate invading pathogens or cancer cells is an ongoing challenge to transplant physicians. Antibody mediated allograft rejection remains problematic in kidney transplantation and is the most common cause of graft loss despite current immunosuppressive therapies. The goal of immunosuppressive therapies is to prevent graft rejection; however, they prevent optimal vaccine responses as well. At the center of acute and chronic antibody mediated rejection and vaccine responses is the B lymphocyte. This review will highlight the role of B cells in alloimmune responses including the dependency on T cells for antibody production. We will discuss the need to improve vaccination rates in transplant recipients and present data on B cell populations and SARS-CoV-2 vaccine response rates in pediatric kidney transplant recipients.

Indexed as

COVID-19COVID-19 VaccinesAllograftsAntibodiesB-LymphocytesChildHumansSARS-CoV-2T-LymphocytesVaccinationAntibodiesCOVID-19 Vaccinesantibody mediated rejectionB cellskidney transplant recipientsSARS CoV2 mRNAvaccinations

Identifiers

PMID35967363
PMCPMC9363634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.