Evidence map›Paper›PMID 35967337›Full record

ArticleFrontiers in immunology2022

Galectin-9 contributes to the pathogenesis of atopic dermatitis

Wenxing Su, Ji Zhang, Shun Yang, Minhui Tang, Yu Shen, Cuiping Liu, Jiang Ji, Marcus Maurer, Qingqing Jiao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Galectin-9: diverse roles in skin disease.Frontiers in allergy · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Wenxing SuDepartment of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou, China.
Ji ZhangDepartment of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou, China.
Shun YangDepartment of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou, China.
Minhui TangDepartment of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yu ShenJiangsu Institute of Clinical Immunology and Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Cuiping LiuJiangsu Institute of Clinical Immunology and Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jiang JiDepartment of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou, China.
Marcus MaurerInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Qingqing JiaoDepartment of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
First Affiliated Hospital of Soochow University · CNSoochow University · CNChina National Nuclear Corporation · CNFreie Universität Berlin · DESecond Affiliated Hospital of Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atopic dermatitis (AD), a common type 2 inflammatory disease, is driven by T helper (T Objectives: To characterize the role of TIM-3 and Gal-9 in the pathogenesis of AD and underlying mechanisms. Methods: We assessed the expression of Gal-9 and TIM-3 in 30 AD patients, to compare them with those of 30 healthy controls (HC) and to explore possible links with disease features including AD activity (SCORAD), IgE levels, and circulating eosinophils and B cells. We also determined the effects of Gal-9 on T cells from the AD patients. Results: Our AD patients had markedly higher levels of serum Gal-9 and circulating TIM-3-expressing T Conclusion: Our findings suggest thatGal-9,

Indexed as

Dermatitis, AtopicGalectinsHepatitis A Virus Cellular Receptor 2HumansImmunoglobulin EMucin-3GalectinsHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Immunoglobulin ELGALS9 protein, humanMucin-3atopic dermatitisGalectin-9 (Gal-9)T cell immunoglobulin- and mucin-domain-containing molecules-3 (TIM-3)TH17 cellsTH1 cellsTH22 cellsTH2 cells

Identifiers

PMID35967337
PMCPMC9364826
OpenAlexW4286698347

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.