Evidence map›Paper›PMID 35967315›Full record

ArticleFrontiers in immunology2022

The importance of taking ART appropriately in children and adolescents with HIV-1 to reach the highest capacity of immune function later in life.

Katrine Schou Sandgaard, Triantafylia Gkouleli, Teresa Attenborough, Stuart Adams, Deena Gibbons, Mette Holm, Sarah Eisen, Helen Baxendale, Anita De Rossi, Savita Pahwa and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Evolution of CD4 T-Cell Count With Age in a Cohort of Young People Growing Up With Perinatally Acquired Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 6 countries.

Katrine Schou SandgaardInfection, Immunity and Inflammation, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Triantafylia GkouleliInfection, Immunity and Inflammation, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Teresa AttenboroughInfection, Immunity and Inflammation, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Stuart AdamsGenetics and Rare Diseases, Great Ormond Street Hospital for Children, London, United Kingdom.
Deena GibbonsPeter Gorer Department of Immunobiology, Kings College London, London, United Kingdom.
Mette HolmDepartment of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
Sarah EisenTropical Diseases, University College London Hospital, London, United Kingdom.
Helen BaxendaleClinical Immunology Department, Royal Papworth Hospital, Cambridge, United Kingdom.
Anita De RossiDepartment of Mother and Child Health, University of Padova, Padova, Italy.
Savita PahwaSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United States.
Benny ChainUniversity College London (UCL) Division of Infection and Immunity, University College London (UCL) Cruciform Building, London, United Kingdom.
Athina S GkaziGenetics and Rare Diseases, Great Ormond Street Hospital for Children, London, United Kingdom.
Nigel KleinInfection, Immunity and Inflammation, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
University College London · GBGreat Ormond Street Hospital · GBInstitute of Infection and Immunity · CAAarhus University Hospital · DKKing's College London · GBPapworth Hospital · GBUniversity of Miami · USUniversity of Padua · IT

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GWENDOLYN Barbara SCOTT · 2007 to 2026
$33.8M
NIAID NIH HHS P30 AI073961
6 · The paper itself

Abstract

Current antiretroviral therapy (ART) guidelines recommend treating all children with HIV-1 infection. This has changed from the broader use of ART to treat children to improve morbidity and minimise mortality. However, prior to current recommendations, not everyone with HIV-1 received timely treatment. What happens to the paediatric immune system when HIV-1 replication is not appropriately supressed remains unclear. 11 samples from adolescents with HIV-1 on ART and uninfected controls in the UK, aged 12-25 years, were examined; overall, adolescents with CD4

Indexed as

HIV-1HIV InfectionsHIV SeropositivityAdolescentAdultAnti-Retroviral AgentsChildHumansImmunityReceptors, Antigen, T-CellYoung AdultAnti-Retroviral AgentsReceptors, Antigen, T-Cellantiretroviral therapy (ART)childrenhigh throughout sequencingHIV-1immune reconstitutionT cell receptor clonal expansionsT cell receptor repertoiresthymic output

Identifiers

PMID35967315
PMCPMC9364750
OpenAlexW4288068124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.