Evidence map›Paper›PMID 35967054›Full record

ArticleACS omega2022

Exploring the Effect of Glycerol and Hydrochloric Acid on Mesoporous Silica Synthesis: Application in Insulin Loading.

May Kyaw Oo, Batoul Alallam, Abd Almonem Doolaanea, Alfi Khatib, Farahidah Mohamed, Bappaditya Chatterjee

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

May Kyaw OoPharmaceutical Technology Department, Kulliyah of Pharmacy, International Islamic University Malaysia, 25200 Kuantan Pahang, Malaysia.
Batoul AlallamAdvanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Penang, Malaysia.
Abd Almonem DoolaaneaPharmaceutical Technology Department, Kulliyah of Pharmacy, International Islamic University Malaysia, 25200 Kuantan Pahang, Malaysia.
Alfi KhatibDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Malaysia.
Farahidah MohamedPharmaceutical Technology Department, Kulliyah of Pharmacy, International Islamic University Malaysia, 25200 Kuantan Pahang, Malaysia.
Bappaditya ChatterjeeShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, 400056 Mumbai, India.ORCID https://orcid.org/0000-0003-1816-6028
International Islamic University Malaysia · MYNarsee Monjee Institute of Management Studies · INUniversiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesoporous silica (MPS), a carrier for active pharmaceutical ingredients, has a wide range of particle and pore morphology. A thorough understanding of ingredients used in MPS synthesis is an important prerequisite for optimizing its physicochemical characteristics. The present study aimed to evaluate the effect of glycerol and hydrochloric acid on the characteristics of synthesized MPS. Ordered MPS materials were synthesized using the pluronic P123 template and tetraethyl orthosilicate (TEOS) precursor. A three-level factorial design was employed to study the interaction between glycerol and hydrochloric acid. The optimized MPS particles were reasonably uniform in shape (short and rod-shaped) and < 1 μm in size with a smooth surface morphology. The nitrogen adsorption-desorption analysis revealed that the uniform cylindrical pores of the prepared MPS had a diameter > 5 nm and a total surface area > 500 m

Identifiers

PMID35967054
PMCPMC9366981
OpenAlexW4288039793

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.