ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2022
Madelung's Disease: Analysis of Clinical Characteristics, Fatty Mass Distribution, Comorbidities and Treatment of 54 Patients in China.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Endocrine manifestations of Madelung disease: A rare case report presenting with life-threatening alcohol-related hypoglycemic coma.Medicine · 2026Article
- Madelung Disease Associated With Bilateral Avascular Necrosis of the Femoral Head: A Case Report of a Rare Disorder.Cureus · 2026Article
- Giant Cervical Lipoma: The First Documented Case Report From Ethiopia.Clinical case reports · 2026Article
- Giant lipoma with an unusual anatomical location successfully managed in a resource-limited setting: a case report.Journal of surgical case reports · 2026Article
- Benign Symmetric Lipomatosis of the Tongue With Dysgeusia: A Case Report and Literature Review.Cureus · 2025Article
- Case Report of a patient with Madelung's disease combined with alcoholic liver disease and liver cirrhosis.Frontiers in medicine · 2025Article
- Madelung's disease -a case series from a single-center experience.Frontiers in surgery · 2025Article
- Review
- A case report on Madelung's disease and comprehensive review of the literature.Orphanet journal of rare diseases · 2024Review
- Perineal Benign Symmetric Lipomatosis in a Female Patient: A Case Report.The American journal of case reports · 2024Article
- Madelung's Disease Evolving to Liposarcoma: An Uncommon Encounter.Life (Basel, Switzerland) · 2024Article
- Madelung disease with postoperative priapism and multiple venous thromboses: case report and literature review.Frontiers in cardiovascular medicine · 2024Article
- Case report: a case report of excision of giant lipoma in the posterior neck.Frontiers in oncology · 2024Article
- Shedding Light on Multiple Symmetric Lipomatosis: An Overlooked Syndrome in the Evaluation of Obesity.The American journal of case reports · 2023Article
- A Case Report of Madelung's Disease.Archives of plastic surgery · 2023Article
- Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Madelung's disease (MD) is a rare disease characterized by the deposition of unencapsulated fat masses on the face, neck, chest, back and other areas of patients. The aim of the study was to analyze the clinical characteristics, comorbidities and treatment of MD in Chinese populations. Patients and Methods: We retrospectively reviewed the medical records of 54 patients who were diagnosed with MD at the Affiliated Hospital of Qingdao University and Qingdao Municipal Hospital from January 2005 to February 2021 and collected the subjects' demographic information, clinical indicators, location of fat deposits, treatment, complications and prognostic data. Results: Among 54 MD patients in the study, only 1 (1.85%) was female, and the subjects had an average age of 56.65 ± 7.93 years. More than 70% of patients had a history of long-term smoking or/and alcohol abuse. In our study, type I accounted for approximately 61.11% of cases according to Donhauser's classification, and almost all patients had neck fat deposition. MD patients often have multiple comorbidities across several systems, such as the endocrine, digestive, circulatory, urinary, and neurological systems. Among these, endocrine system diseases were the most common comorbidities in our study, accounting for 81.48%. Notably, up to 20.37% of cases were complicated with cancer, especially digestive system tumors. More than 70% of the patients received surgical treatment, and nearly 40% experienced postoperative recurrence. Conclusion: Considering that MD patients often have comorbidities of multiple systems and that a small number of cases are even complicated by cancer, we recommend that clinicians comprehensively assess a patient's condition and complications, advocate that patients quit consuming alcohol and smoking as soon as possible, establish healthy dietary and living habits, and formulate individualized and comprehensive diagnosis and treatment plans.
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