Evidence map›Paper›PMID 35966797›Full record

ArticleFrontiers in aging neuroscience2022

Associations of multiple visual rating scales based on structural magnetic resonance imaging with disease severity and cerebrospinal fluid biomarkers in patients with Alzheimer's disease.

Mei-Dan Wan, Hui Liu, Xi-Xi Liu, Wei-Wei Zhang, Xue-Wen Xiao, Si-Zhe Zhang, Ya-Ling Jiang, Hui Zhou, Xin-Xin Liao, Ya-Fang Zhou and 5 more

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Genetic variability ofHeliyon · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mei-Dan WanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hui LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xi-Xi LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Wei-Wei ZhangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Xue-Wen XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Si-Zhe ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Ya-Ling JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hui ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xin-Xin LiaoNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China.
Ya-Fang ZhouNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China.
Bei-Sha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Jun-Ling WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Ji-Feng GuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Bin JiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lu ShenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationships between multiple visual rating scales based on structural magnetic resonance imaging (sMRI) with disease severity and cerebrospinal fluid (CSF) biomarkers in patients with Alzheimer's disease (AD) were ambiguous. In this study, a total of 438 patients with clinically diagnosed AD were recruited. All participants underwent brain sMRI scan, and medial temporal lobe atrophy (MTA), posterior atrophy (PA), global cerebral atrophy-frontal sub-scale (GCA-F), and Fazekas rating scores were visually evaluated. Meanwhile, disease severity was assessed by neuropsychological tests such as the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Clinical Dementia Rating (CDR). Among them, 95 patients were tested for CSF core biomarkers, including Aβ

Indexed as

Alzheimer’s diseasecerebrospinal fluidglobal cerebral frontal atrophymedial temporal lobe atrophyposterior atrophyvisual rating scalewhite matter lesions

Identifiers

PMID35966797
PMCPMC9374170

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.