ArticleFrontiers in aging neuroscience2022
Clinical determinants and neural correlates of presbyphagia in community-dwelling older adults.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Presbyphagia: A Conceptual Analysis of Contemporary Proposals and Their Influences on Clinical Diagnosis.Dysphagia · 2024Pooled it
- The prevalence of presbyphagia in older adults: a systematic review and meta-analysis.Wiener klinische Wochenschrift · 2024Pooled it
- The Relationship between Swallowing Muscle Mass and Tongue Muscle Strength and Endurance in Head and Neck Cancer Patients.Dysphagia · 2026Article
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- [Oropharyngeal dysphagia as a neurogeriatric syndrome].Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- Effect of Fluid Thickening with a Gum-Based Thickening Product in Older Patients with Structural or Mild Oropharyngeal Dysphagia.Nutrients · 2026Article
- The Association of Dysphagia with Social Isolation, Mental Health, and Cognition in Older Adults.Dysphagia · 2026Article
- Mapping neurogenic dysphagia diagnostics in Germany: accessibility, implementation practices, and barriers to swallowing endoscopy.Neurological research and practice · 2026Article
- Article
- Marmoset (Callithrix jacchus) Swallowing Physiology: Novel Dysphagia Model Across Lifespan.Integrative and comparative biology · 2026Article
- Olfaction and Coronary Heart Disease.JAMA otolaryngology-- head & neck surgery · 2026Article
- Acoustic Vowel Metrics as Correlates of Dysphagia and Dysarthria in Brainstem Neurodegenerative Diseases.Audiology research · 2025Article
- [Associations of depression, daily singing, and healthy lifestyle on the risk of dysphagia and frailty among community-dwelling older adults: A cross-sectional correlation study].Journal of Korean gerontological nursing · 2025Article
- Predictors of Pneumonia in Patients With Penetration-Aspirations Detected on Fiberoptic Endoscopic Evaluation of Swallowing.Dysphagia · 2025Article
- Neurogenic Dysphagia: Peripheral and Central Neuromodulation.Clinics and practice · 2025Review
- Age-Related Changes in Marmoset (Callithrix jacchus) Feeding Behavior and Physiology: Insights of Masticatory and Swallowing Functions.American journal of primatology · 2025Article
- Cognitive decline limits compensatory resource allocation within the aged swallowing network.GeroScience · 2025Article
- Risk Factors for Oropharyngeal Dysphagia in Older Adults - Evidence from Consorci Sanitari Del Maresme and Mataró University Hospital, Catalonia, Spain.Aging and disease · 2025Article
- Endoscopic characterization of oropharyngeal dysphagia in patients with dementia.Frontiers in aging · 2025Article
- Observational
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: "Presbyphagia" refers to characteristic age-related changes in the complex neuromuscular swallowing mechanism. It has been hypothesized that cumulative impairments in multiple domains affect functional reserve of swallowing with age, but the multifactorial etiology and postulated compensatory strategies of the brain are incompletely understood. This study investigates presbyphagia and its neural correlates, focusing on the clinical determinants associated with adaptive neuroplasticity. Materials and methods: 64 subjects over 70 years of age free of typical diseases explaining dysphagia received comprehensive workup including flexible endoscopic evaluation of swallowing (FEES), magnetoencephalography (MEG) during swallowing and pharyngeal stimulation, volumetry of swallowing muscles, laboratory analyzes, and assessment of hand-grip-strength, nutritional status, frailty, olfaction, cognition and mental health. Neural MEG activation was compared between participants with and without presbyphagia in FEES, and associated clinical influencing factors were analyzed. Presbyphagia was defined as the presence of oropharyngeal swallowing alterations e.g., penetration, aspiration, pharyngeal residue pooling or premature bolus spillage into the piriform sinus and/or laryngeal vestibule. Results: 32 of 64 participants showed swallowing alterations, mainly characterized by pharyngeal residue, whereas the airway was rarely compromised. In the MEG analysis, participants with presbyphagia activated an increased cortical sensorimotor network during swallowing. As major clinical determinant, participants with swallowing alterations exhibited reduced pharyngeal sensation. Presbyphagia was an independent predictor of a reduced nutritional status in a linear regression model. Conclusions: Swallowing alterations frequently occur in otherwise healthy older adults and are associated with decreased nutritional status. Increased sensorimotor cortical activation may constitute a compensation attempt to uphold swallowing function due to sensory decline. Further studies are needed to clarify whether the swallowing alterations observed can be considered physiological
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