Evidence map›Paper›PMID 35966515›Full record

ArticleFrontiers in cardiovascular medicine2022

Analysis of the miRNA expression from the adipose tissue surrounding the adrenal neoplasia.

Antonio Concistrè, Luigi Petramala, Francesco Circosta, Priscilla Romagnoli, Maurizio Soldini, Marco Bucci, Domenico De Cesare, Giuseppe Cavallaro, Giorgio De Toma, Francesco Cipollone and 1 more

Open access · goldAbstract read
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In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Antonio ConcistrèDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Luigi PetramalaDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Francesco CircostaDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Priscilla RomagnoliDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Maurizio SoldiniDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Marco BucciDepartment of Medicine and Aging Sciences, University "Gabriele d'Annunzio" of Chieti-Pescara, Chieti, Italy.
Domenico De CesareDepartment of Medicine and Aging Sciences, University "Gabriele d'Annunzio" of Chieti-Pescara, Chieti, Italy.
Giuseppe CavallaroDepartment of Surgery "Pietro Valdoni, " "Sapienza" University of Rome, Rome, Italy.
Giorgio De TomaDepartment of Surgery "Pietro Valdoni, " "Sapienza" University of Rome, Rome, Italy.
Francesco CipolloneDepartment of Medicine and Aging Sciences, University "Gabriele d'Annunzio" of Chieti-Pescara, Chieti, Italy.
Claudio LetiziaDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Sapienza University of Rome · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Primary aldosteronism (PA) is characterized by several metabolic changes such as insulin resistance, metabolic syndrome, and adipose tissue (AT) inflammation. Mi(cro)RNAs (miRNAs) are a class of non-coding small RNA molecules known to be critical regulators in several cellular processes associated with AT dysfunction. The aim of this study was to evaluate the expression of some miRNAs in visceral and subcutaneous AT in patients undergoing adrenalectomy for aldosterone-secreting adrenal adenoma (APA) compared to the samples of AT obtained in patients undergoing adrenalectomy for non-functioning adrenal mass (NFA). Methods: The quantitative expression of selected miRNA using real-time PCR was analyzed in surrounding adrenal neoplasia, peri-renal, and subcutaneous AT samples of 16 patients with adrenalectomy (11 patients with APA and 5 patients with NFA). Results: Real-time PCR cycles for miRNA-132, miRNA-143, and miRNA-221 in fat surrounding adrenal neoplasia and in peri-adrenal AT were significantly higher in APA than in patients with NFA. Unlike patients with NFA, miRNA-132, miRNA-143, miRNA-221, and miRNA-26b were less expressed in surrounding adrenal neoplasia AT compared to subcutaneous AT in patients with APA. Conclusion: This study, conducted on tissue expression of miRNAs, highlights the possible pathophysiological role of some miRNAs in determining the metabolic alterations in patients with PA.

Indexed as

adipose tissueadrenalectomyaldosterone-secreting adrenal adenomamiRNAsprimary aldosteronism

Identifiers

PMID35966515
PMCPMC9366211
OpenAlexW4288077552

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