Evidence map›Paper›PMID 35966168›Full record

ArticleNano research2019

Single small molecule-assembled nanoparticles mediate efficient oral drug delivery.

Xin Yang, Chao Ma, Zeming Chen, Jun Liu, Fuyao Liu, Rongbin Xie, Haitian Zhao, Gang Deng, Ann T Chen, Ningbo Gong and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Natural Products from Herbal Medicine Self-Assemble into Advanced Bioactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Xin YangSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China.
Chao MaCollege of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China.
Zeming ChenDepartment of Neurosurgery, Yale University, New Haven, CT, 06510, USA.
Jun LiuDepartment of Neurosurgery, Yale University, New Haven, CT, 06510, USA.
Fuyao LiuDepartment of Neurosurgery, Yale University, New Haven, CT, 06510, USA.
Rongbin XieDepartment of Chemistry, Beijing Normal University, Beijing, 100875, China.
Haitian ZhaoSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China.
Gang DengDepartment of Neurosurgery, Yale University, New Haven, CT, 06510, USA.
Ann T ChenDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06510, USA.
Ningbo GongBeijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Lei YaoSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China.
Pengjian ZuoSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China.
Kangkang ZhiSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China.
Jiacheng WangSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China.
Xiaobin GaoDepartment of Pathology, Yale University, New Haven, CT, 06510, USA.
Jing WangSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China.
Louzhen FanDepartment of Chemistry, Beijing Normal University, Beijing, 100875, China.
Jiangbing ZhouDepartment of Neurosurgery, Yale University, New Haven, CT, 06510, USA.
Yale University · USHarbin Institute of Technology · CNBeijing Normal University · CNBeijing Forestry University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Systemic gene therapy for glioblastomaR01NS095817 · NINDS · YALE UNIVERSITY · PI ZHOU, JIANGBING · 2016 to 2020
$1.8M
NINDS NIH HHS R01 NS095817
6 · The paper itself

Abstract

Oral drug delivery, which requires surviving the harsh environment in the gastrointestinal (GI) tract and penetrating the intestinal epithelium, has not been achieved using simple formulation nanoparticles (NPs). Medicinal natural products (MNPs) have been widely used in traditional medicine for disease management through oral consumption. However, most pharmacologically active compounds within MNPs do not have the properties suitable for oral applications. We hypothesize that some MNPs contain natural nanomaterials that can convert those compounds into oral formulations by forming NPs. After screening 66 MNPs, we identified five classes of small molecules that form NPs, many of which are capable of efficient drug encapsulation and GI penetration. We show that one of them, dehydrotrametenolic acid (DTA), is capable of mediating oral delivery for effective disease treatment. We determine that DTA NPs assemble through hydrogen bonding and penetrate the GI tract via apical sodium-dependent bile acid transporter. Our study reveals a novel class of single component, small molecule- assembled NPs for oral drug delivery, and suggests a novel approach to modernizing MNPs through nanomaterial discovery.

Indexed as

dehydrotrametenolic acidnanoparticlenatural materialoral drug delivery

Identifiers

PMID35966168
PMCPMC9369969
OpenAlexW2963289784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.