Evidence map›Paper›PMID 35965961›Full record

ArticleDrug design, development and therapy2022

The Preventive and Therapeutic Effects of Ajwa Date Fruit Extract Against Acute Diclofenac Toxicity-Induced Colopathy: An Experimental Study.

Shaimaa Mohamed Abdelfattah Hassan, Moutasem Salih Aboonq, Emad A Albadawi, Yasmeen Aljehani, Hytham Mahmoud Abdel-Latif, Reham A Mariah, Noha M Shafik, Tamer M Soliman, Abdelhady Ragab Abdel-Gawad, Faten M Omran and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug design, development and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 2 countries.

Shaimaa Mohamed Abdelfattah HassanHistology and Cell Biology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.ORCID 0000-0001-6573-1363
Moutasem Salih AboonqDepartment of Medical Physiology, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia.ORCID 0000-0002-9137-941X
Emad A AlbadawiAnatomy and Embryology Department, Taibah College of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
Yasmeen AljehaniAcademic Affairs, Training and Research (CAO), King Salman Bin Abdelaziz Medical City, Al-Madinah Al-Munawwarah, Saudi Arabia.
Hytham Mahmoud Abdel-LatifDepartment of Medical Pharmacology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.
Reham A MariahDepartment of Medical Biochemistry, Tanta Faculty of Medicine, Tanta University, Tanta, Egypt.
Noha M ShafikDepartment of Medical Biochemistry, Tanta Faculty of Medicine, Tanta University, Tanta, Egypt.
Tamer M SolimanDepartment of Clinical Pathology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.
Abdelhady Ragab Abdel-GawadDepartment of Clinical Pathology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.ORCID 0000-0002-2574-9953
Faten M OmranDepartment of Medical Pharmacology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.
Wafaa A AbdellahDepartment of Medical Pharmacology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.
Ahmed ShehataDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia.ORCID 0000-0002-5049-1595
Husam ShahadaDepartment of Pharmaceutical Care, Uhud Hospital, Al-Madinah, Saudi Arabia.
Hussam H BaghdadiDepartment of Clinical Biochemistry, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia.
Hanan Yousef AlyDepartment of Neuropsychiatry, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.
Alfarazdeg SaadDepartment of Clinical Biochemistry, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia.
Manal Mohamed Helmy NaboDepartment of Pediatrics, Al-Rayyan Medical College, Al-Madinah, Saudi Arabia.
Abdullah AlmilaibaryFamily and Community Medicine Department, Faculty of Medicine, Albaha University, Albaha, Saudi Arabia.
Heba M EltahirDepartment of pharmacology and toxicology, Biochemistry Division, Taibah University, Medina, Saudi Arabia.
Salah Mohamed El SayedDepartment of Clinical Biochemistry, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia.
Mustafa A M Abu-ElnagaDepartment of Anatomy, College of Medicine, Al-Rayyan Medical Colleges, Al-Madinah, Saudi Arabia.
Yasser M ElbastawisyAnatomy and Embryology Department, Taibah College of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
Sohag University · EGTaibah University · SATanta University · EGAl-Azhar University · EGAl Baha University · SABeni-Suef University · EGIslamic University of Madinah · SAMansoura University · EGMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies regarding treatment of acute toxicity with diclofenac (ATD) are quite few. Diclofenac is commonly prescribed in neurology, psychiatry, and general medicine practice. This study investigated possible colon-protective effects exerted by Ajwa date fruit extract (ADFE), a prophetic medicine remedy native to Al-Madinah, Saudi Arabia against ATD. Phytochemicals in ADFE as gallic acid and quercetin have reported protective effects against ATD. Methods: Total phenols and flavonoids in ADFE were estimated as equivalents to gallic acid and quercetin. Four experimental groups were allocated each of six rats: control group, ATD group received a single dose of 150 mg diclofenac intraperitoneally, toxicity prevention group received a single dose of ADFE orally followed 4 hours later by diclofenac injection, and toxicity treatment group received a similar diclofenac dose followed 4 hours later by a single dose of ADFE. Four days later, animals were sacrificed. Histological and biochemical examinations were done. Results: ADFE has a total phenolic content of 331.7 gallic acid equivalent/gram extract and a total flavonoid content of 70.23 quercetin equivalent/gram. ATD significantly increased oxidative stress markers as serum malondialdehyde (MDA) and hydrogen peroxide (H Conclusion: ADFE is rich in quercetin and gallic acid equivalents that exert potent antitoxic effects. ADFE is strongly recommended for preventive and therapeutic colon effects against ATD.

Indexed as

DiclofenacPhoeniceaeAnimalsAntioxidantsFlavonoidsGallic AcidHydrogen PeroxidePhenolsPlant ExtractsQuercetinRatsAntioxidantsDiclofenacFlavonoidsGallic AcidHydrogen PeroxidePhenolsPlant ExtractsQuercetinacute toxicityAjwa date extractcolondiclofenachistologypolyphenols and flavonoids

Identifiers

PMID35965961
PMCPMC9366708
OpenAlexW4289936630

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.