Evidence map›Paper›PMID 35965838›Full record

ArticleBrain, behavior, & immunity - health2022

Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia.

Johannes Teller, Carolin Jung, Justus B H Wilke, Svea-Dorothée Schimmelpfennig, Martin Hindermann, Lukas Hinken, Maria M Gabriel, Christine Fegbeutel, Andreas Schäfer, Hans Laser and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Johannes TellerDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Carolin JungDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Justus B H WilkeClinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, City Campus, Göttingen, Germany.
Svea-Dorothée SchimmelpfennigDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Martin HindermannClinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, City Campus, Göttingen, Germany.
Lukas HinkenDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Maria M GabrielDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Christine FegbeutelDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Andreas SchäferDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Hans LaserCenter for Information Management, Hannover Medical School, Hannover, Germany.
Ralf LichtinghagenInstitute of Clinical Chemistry, Hannover Medical School, Hannover, Germany.
Hans WorthmannDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Karin WeissenbornDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Hannelore EhrenreichClinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, City Campus, Göttingen, Germany.
Medizinische Hochschule Hannover · DEMax Planck Institute for Multidisciplinary Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically - transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as 'immunoprecipitator' of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.

Indexed as

BBB breakdownBlood-brain-barrier openingCardiac surgeryHeart diseaseImmunoglobulin classSeroprevalenceSerum proteins

Identifiers

PMID35965838
PMCPMC9372600
OpenAlexW4289745692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.