Evidence map›Paper›PMID 35964762›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2022

Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe.

Byunghang Ha, Kaitlyn Liang, Cheng Liu, Stavros Melemenidis, Rakesh Manjappa, Vignesh Viswanathan, Neeladrisingha Das, Ramish Ashraf, Brianna Lau, Luis Soto and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Direct Measurements of FLASH-Induced Changes in Intracellular Oxygenation.International journal of radiation oncology, biology, physics · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Byunghang HaDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Kaitlyn LiangDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
Cheng LiuMolecular Imaging Program at Stanford, Departments of Radiology and Chemistry, Stanford University, Stanford, CA 94305, USA.
Stavros MelemenidisDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Rakesh ManjappaDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Vignesh ViswanathanDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Neeladrisingha DasDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Ramish AshrafDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Brianna LauDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Luis SotoDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Edward E GravesDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Jianghong RaoMolecular Imaging Program at Stanford, Departments of Radiology and Chemistry, Stanford University, Stanford, CA 94305, USA.
Billy W LooDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Guillem PratxDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA. Electronic address: pratx@stanford.edu.

Funding

Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
Noninvasive deep-tissue single-cell imaging and nanoprobe developmentR01GM128089 · NIGMS · STANFORD UNIVERSITY · PI CHU, STEVEN, RAO, JIANGHONG · 2018 to 2021
$2.2M
Oxygen imaging by phosphorescence quenchingU24EB028941 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI VINOGRADOV, SERGEI · 2019 to 2023
$1.6M
NCI NIH HHS P01 CA244091NIBIB NIH HHS U24 EB028941NIGMS NIH HHS R01 GM128089
6 · The paper itself

Abstract

The rapid depletion of oxygen during irradiation at ultra-high dose rate calls for tissue oximeters capable of high temporal resolution. This study demonstrates a water-soluble phosphorescent nanoprobe and fiber-coupled instrument, which together are used to measure the kinetics of oxygen depletion at 200 Hz during irradiation of in vitro solutions.

Indexed as

OximetryOxygenHumansRadiotherapyRadiotherapy DosageOxygenFLASH radiotherapyNanoparticlesOximetryOxygenPhosphorimetry

Identifiers

PMID35964762
PMCPMC11277691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.