ArticleJournal of Alzheimer's disease : JAD2022
DTI Connectometry Analysis Reveals White Matter Changes in Cognitively Impaired World Trade Center Responders at Midlife.
Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence.Ageing research reviews · 2024Pooled it
- Reduced Gray-White Matter Contrast in Chronic Posttraumatic Stress Disorder in World Trade Center Responders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Posttraumatic stress disorder, major depression, and mild cognitive impairment: A cohort study of world trade center responders.Psychiatry research · 2026Article
- MRI signature of brain age underlying post-traumatic stress disorder in World Trade Center responders.Translational psychiatry · 2025Article
- Increased Aβ40 in plasma is associated with severity of exposure to airborne pollutants at the World Trade Center: a cross-sectional study of neurological biomarkers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Neuroplasticity in Post-Traumatic Stress Disorder.Revista de neurologia · 2025Review
- Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.medRxiv : the preprint server for health sciences · 2025Article
- Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders.Life (Basel, Switzerland) · 2023Review
- Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An Integrative Review.Biomedicines · 2023Review
- White matter microstructure and serum biomarkers of inflammation in psychogenic non-epileptic seizures.NeuroImage. Clinical · 2023Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMore than 8% of responders who participated in the search and rescue efforts at the World Trade Center (WTC) following 9/11 developed early-onset cognitive impairment (CI). Approximately 23% were also diagnosed with chronic post-traumatic stress disorder (PTSD).
objectiveTo shed light on the pathophysiology of these WTC-related conditions, we examined diffusion connectometry to identify altered white matter tracts in WTC responders with CI and/or PTSD compared to unaffected responders.
methods99 WTC responders (mean age 56 years) consisting of CI-/PTSD- (n = 27), CI+/PTSD- (n = 25), CI-/PTSD+ (n = 24), and CI+/PTSD+ (n = 23) were matched on age, sex, occupation, race, and education. Cognitive status was determined using the Montreal Cognitive Assessment and PTSD status was determined using the DSM-IV SCID. Diffusion tensor imaging was acquired on a 3T Siemens Biograph mMR scanner. Connectometry analysis was used to examine whole-brain tract-level differences in white matter integrity as reflected by fractional anisotropy (FA) values after adjusting for confounders.
resultsAnalyses identified that FA was negatively correlated with CI and PTSD status in the fornix, cingulum, forceps minor of the corpus callosum and the right uncinate fasciculus. Furthermore, FA was negatively correlated with PTSD status, regardless of CI status in the superior thalamic radiation and the cerebellum.
conclusionThis is the first connectometry study to examine altered white matter tracts in a sample of WTC responders with CI and/or PTSD. Results from this study suggest that WTC responders with early-onset CI may be experiencing an early neurodegenerative process characterized by decreased FA in white matter tracts.
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